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    Mup3 major urinary protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 17842, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mup3provided by MGI
    Official Full Name
    major urinary protein 3provided by MGI
    Primary source
    MGI:MGI:97235
    See related
    Ensembl:ENSMUSG00000066154 AllianceGenome:MGI:97235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MUP15; Mup-3; Mup25; MUPIII
    Summary
    Predicted to enable insulin receptor activity and pheromone binding activity. Involved in response to stilbenoid. Located in extracellular space. Is expressed in liver. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward liver adult (RPKM 346.7) See more
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    Genomic context

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    See Mup3 in Genome Data Viewer
    Location:
    4 B3; 4 32.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62001713..62005554, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62083476..62087317, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene major urinary protein, pseudogene 19 Neighboring gene STARR-seq mESC enhancer starr_10401 Neighboring gene STARR-seq mESC enhancer starr_10403 Neighboring gene STARR-seq mESC enhancer starr_10404 Neighboring gene STARR-seq mESC enhancer starr_10405 Neighboring gene major urinary protein 20 Neighboring gene major urinary protein, pseudogene 21 Neighboring gene STARR-seq mESC enhancer starr_10406 Neighboring gene predicted gene 12909 Neighboring gene STARR-seq mESC enhancer starr_10409 Neighboring gene major urinary protein 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subfamilies of the mouse major urinary protein (MUP) multi-gene family: sequence analysis of cDNA clones and differential regulation in the liver. Kuhn NJ, et al. Nucleic Acids Res, 1984 Aug 10. PMID 6548015, Free PMC Article
    2. Analysis of mouse major urinary protein genes: variation between the exonic sequences of group 1 genes and a comparison with an active gene out with group 1 both suggest that gene conversion has occurred between MUP genes. Clark AJ, et al. EMBO J, 1985 Dec 1. PMID 3004936, Free PMC Article
    3. Identification and characterization of functional genes encoding the mouse major urinary proteins. Held WA, et al. Mol Cell Biol, 1987 Oct. PMID 2824995, Free PMC Article
    4. Nucleotide sequences of liver, lachrymal, and submaxillary gland mouse major urinary protein mRNAs: mosaic structure and construction of panels of gene-specific synthetic oligonucleotide probes. Shahan K, et al. Mol Cell Biol, 1987 May. PMID 3600652, Free PMC Article
    5. Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver. Jiang J, et al. J Biol Chem, 2017 Apr 21. PMID 28258223, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117854

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables insulin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pheromone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to lipid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in energy reserve metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heat generation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotor rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    major urinary protein 3
    Names
    MUP 3
    alpha-2u-globulin III
    major urinary protein 25
    non-group 1/group 2 MUP15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039544.2 → NP_001034633.1  major urinary protein 3 precursor

      See identical proteins and their annotated locations for NP_001034633.1

      Status: VALIDATED

      Source sequence(s)
      AW110320, AW112847, BX088584, CJ043431, D18031, EU882235
      Consensus CDS
      CCDS18234.1
      UniProtKB/Swiss-Prot
      P04939, P97897, Q8VCG6
      UniProtKB/TrEMBL
      Q3KQQ2
      Related
      ENSMUSP00000081579.5, ENSMUST00000084531.11
      Conserved Domains (1) summary
      pfam00061
      Location:38 → 174
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RNA

    1. NR_149826.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AW112866, BX088584, CJ043431, D18031

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      62001713..62005554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010845.1: Suppressed sequence

      Description
      NM_010845.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04939.1 GenPept UniProtKB/Swiss-Prot:P04939

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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