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    MIA2 MIA SH3 domain ER export factor 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 513132, updated on 27-Dec-2024

    Summary

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    Gene symbol
    MIA2
    Gene description
    MIA SH3 domain ER export factor 2
    See related
    BGD:BT27623; Ensembl:ENSBTAG00000006819
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CTAGE5
    Orthologs
    human mouse all
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    Genomic context

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    See MIA2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (49184509..49281682)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 6B Neighboring gene pinin, desmosome associated protein Neighboring gene mortality factor 4-like protein 1 Neighboring gene F-box protein 33 Neighboring gene uncharacterized LOC104975415 Neighboring gene uncharacterized LOC132343373

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC139789

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle cargo loading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum exit site IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cTAGE family member 5; melanoma inhibitory activity protein 2
    Names
    CTAGE family member 5, ER export factor
    CTAGE family, member 5
    melanoma inhibitory activity 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49184509..49281682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005222083.5 → XP_005222140.2  melanoma inhibitory activity protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LM15, A0A3Q1MC42
      Related
      ENSBTAP00000060892.2, ENSBTAT00000078548.2
      Conserved Domains (4) summary
      cd11892
      Location:31 → 103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      cl25732
      Location:781 → 1074
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:679 → 852
      DUF3084; Protein of unknown function (DUF3084)
      cl26761
      Location:108 → 500
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    2. XM_005222085.5 → XP_005222142.2  melanoma inhibitory activity protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MC42
      Conserved Domains (4) summary
      cd11892
      Location:31 → 103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      cl25732
      Location:781 → 1074
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:679 → 852
      DUF3084; Protein of unknown function (DUF3084)
      cl26761
      Location:108 → 500
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    3. XM_005222084.5 → XP_005222141.2  melanoma inhibitory activity protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MC42, A0A3Q1MUH0
      Related
      ENSBTAP00000074216.2, ENSBTAT00000085093.2
      Conserved Domains (3) summary
      cd11892
      Location:31 → 103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      cl25732
      Location:707 → 1049
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26761
      Location:108 → 500
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    4. XM_005222086.5 → XP_005222143.2  melanoma inhibitory activity protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MC42
      Conserved Domains (3) summary
      cd11892
      Location:31 → 103
      SH3_MIA2; Src Homology 3 domain of Melanoma Inhibitory Activity 2 protein
      cl25732
      Location:707 → 1049
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26761
      Location:108 → 500
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    5. XM_005222089.5 → XP_005222146.1  melanoma inhibitory activity protein 2 isoform X8

      UniProtKB/TrEMBL
      F1ME53
      Conserved Domains (2) summary
      pfam06409
      Location:392 → 465
      NPIP; Nuclear pore complex interacting protein (NPIP)
      cl12013
      Location:306 → 440
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_005222090.5 → XP_005222147.1  melanoma inhibitory activity protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A3Q1LTL6
      Related
      ENSBTAP00000060421.2, ENSBTAT00000079365.2
      Conserved Domains (3) summary
      pfam06409
      Location:383 → 456
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam09728
      Location:63 → 318
      Taxilin; Myosin-like coiled-coil protein
      cl12013
      Location:297 → 431
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_005222091.5 → XP_005222148.1  melanoma inhibitory activity protein 2 isoform X10

      See identical proteins and their annotated locations for XP_005222148.1

      UniProtKB/TrEMBL
      F1ME53
      Conserved Domains (1) summary
      cl25732
      Location:144 → 437
      SMC_N; RecF/RecN/SMC N terminal domain

    8. XM_005222087.4 → XP_005222144.1  melanoma inhibitory activity protein 2 isoform X6

      UniProtKB/TrEMBL
      F1MDR5, F1ME53
      Related
      ENSBTAP00000043043.2, ENSBTAT00000045673.3
      Conserved Domains (4) summary
      pfam04871
      Location:164 → 288
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam06409
      Location:398 → 471
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam09728
      Location:69 → 333
      Taxilin; Myosin-like coiled-coil protein
      cl12013
      Location:312 → 446
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_005222093.5 → XP_005222150.1  melanoma inhibitory activity protein 2 isoform X10

      See identical proteins and their annotated locations for XP_005222150.1

      UniProtKB/TrEMBL
      F1ME53
      Conserved Domains (1) summary
      cl25732
      Location:144 → 437
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_024982081.2 → XP_024837849.1  melanoma inhibitory activity protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LPK3, A0A3Q1MN66
      Related
      ENSBTAP00000073335.2, ENSBTAT00000070362.2
      Conserved Domains (1) summary
      cl25732
      Location:173 → 466
      SMC_N; RecF/RecN/SMC N terminal domain

    11. XM_024982087.2 → XP_024837855.1  melanoma inhibitory activity protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A3Q1LPK3
      Conserved Domains (1) summary
      cl25732
      Location:173 → 466
      SMC_N; RecF/RecN/SMC N terminal domain

    12. XM_005222088.5 → XP_005222145.1  melanoma inhibitory activity protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LPK3
      Conserved Domains (4) summary
      pfam04871
      Location:161 → 285
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam06409
      Location:395 → 468
      NPIP; Nuclear pore complex interacting protein (NPIP)
      pfam09728
      Location:75 → 330
      Taxilin; Myosin-like coiled-coil protein
      cl12013
      Location:309 → 443
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    13. XM_024982088.2 → XP_024837856.1  melanoma inhibitory activity protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A3Q1LPK3, A0AAA9SJQ7
      Related
      ENSBTAP00000084048.1, ENSBTAT00000092842.1
      Conserved Domains (1) summary
      cl25732
      Location:99 → 441
      SMC_N; RecF/RecN/SMC N terminal domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001075599.1: Suppressed sequence

      Description
      NM_001075599.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: CTAGE5 (GeneID:4253).
    Nucleotide Protein Strain
    Heading Accession and Version

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