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    NEK4 NIMA related kinase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 511455, updated on 30-Jan-2025

    Summary

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    Official Symbol
    NEK4provided by VGNC
    Official Full Name
    NIMA related kinase 4provided by VGNC
    Primary source
    VGNC:VGNC:31995
    See related
    BGD:BT19387; EnsemblRapid:ENSBTAG00070032112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NEK4 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (48124632..48152516)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 1 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene small nucleolar RNA SNORD69 Neighboring gene G protein nucleolar 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159441

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek4
    Names
    NIMA (never in mitosis gene a)-related kinase 4
    NP_001095414.1
    XP_005222831.1
    XP_024838351.1
    XP_024838353.1
    XP_024838354.1
    XP_059735581.1
    XP_059735582.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101944.2 → NP_001095414.1  serine/threonine-protein kinase Nek4

      See identical proteins and their annotated locations for NP_001095414.1

      Status: PROVISIONAL

      Source sequence(s)
      BC149593
      UniProtKB/TrEMBL
      A0AAA9U182, A6QQ15
      Related
      ENSBTAP00070044270.1, ENSBTAT00070072673.1
      Conserved Domains (2) summary
      smart00220
      Location:1 → 179
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 179
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48124632..48152516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024982583.2 → XP_024838351.1  serine/threonine-protein kinase Nek4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9U182, F6RG88
      Conserved Domains (1) summary
      cd08223
      Location:5 → 261
      STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

    2. XM_005222774.5 → XP_005222831.1  serine/threonine-protein kinase Nek4 isoform X2

      UniProtKB/TrEMBL
      A0AAA9U182
      Related
      ENSBTAP00070044249.1, ENSBTAT00070072632.1
      Conserved Domains (2) summary
      smart00220
      Location:6 → 261
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08223
      Location:5 → 261
      STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

    3. XM_024982585.2 → XP_024838353.1  serine/threonine-protein kinase Nek4 isoform X3

      UniProtKB/TrEMBL
      A0AAA9U182
      Conserved Domains (1) summary
      cd08223
      Location:5 → 261
      STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

    4. XM_059879599.1 → XP_059735582.1  serine/threonine-protein kinase Nek4 isoform X5

    5. XM_059879598.1 → XP_059735581.1  serine/threonine-protein kinase Nek4 isoform X4

    6. XM_024982586.2 → XP_024838354.1  serine/threonine-protein kinase Nek4 isoform X6

      UniProtKB/TrEMBL
      A0AAA9U182
      Conserved Domains (1) summary
      cl21453
      Location:1 → 179
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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