Jchain immunoglobulin joining chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jchainprovided by MGI
Official Full Name: immunoglobulin joining chainprovided by MGI
Primary source: MGI:MGI:96493
See related: Ensembl:ENSMUSG00000067149 AllianceGenome:MGI:96493
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igj; Jch; 9530090F24Rik
Summary: Enables IgA binding activity and protein-macromolecule adaptor activity. Contributes to immunoglobulin receptor binding activity. Predicted to be involved in several processes, including defense response to symbiont; glomerular filtration; and positive regulation of respiratory burst. Part of dimeric IgA immunoglobulin complex. Is expressed in intestine; serum; and spleen. Orthologous to human JCHAIN (joining chain of multimeric IgA and IgM). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 384.0), small intestine adult (RPKM 358.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.7 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (88667663..88675667, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (88519809..88527897, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Crlz1 increased the IgJ enhancer activity due to its CBF sites, as verified by both the absence of Crlz1 effect on the CBF-site mutated IgJ enhancer and the presence of transcriptional synergy between Crlz1 and CBFbeta.
Title: Crlz1 activates transcription by mobilizing cytoplasmic CBFbeta into the nucleus.
identifies the HSS3/4 enhancer of Crlz1-IgJ locus as another target of EBG in early developmental stage of B cells
Title: The HSS3/4 enhancer of Crlz1-IgJ locus is another target of EBF in the pre-B cell stage of B cell development.
H3 and H4 histones toward the chromatin of the Crlz1 gene are found to be hyperacetylated, especially on H3, in the pre-B cells, whereas those toward the chromatin of the IgJ gene are found to be hyperacetylated in the plasma cells
Title: Stage-specific expression of two neighboring Crlz1 and IgJ genes during B cell development is regulated by their chromatin accessibility and histone acetylation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igj (e-PCR), detects polymorphism
- UniSTS:461922

Igj (e-PCR), detects polymorphism
- UniSTS:461923

J00544 (e-PCR)
- UniSTS:159390

AI323815 (e-PCR)
- UniSTS:179196

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgA binding	IDA Inferred from Direct Assay more info	PubMed
enables IgA binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
contributes_to immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to immunoglobulin receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
contributes_to peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IEA Inferred from Electronic Annotation more info
contributes_to phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in glomerular filtration	IEA Inferred from Electronic Annotation more info
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dimeric IgA immunoglobulin complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of dimeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of monomeric IgA immunoglobulin complex	IEA Inferred from Electronic Annotation more info
part_of monomeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of pentameric IgM immunoglobulin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of pentameric IgM immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of pentameric IgM immunoglobulin complex	ISS Inferred from Sequence or Structural Similarity more info
part_of secretory IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of secretory IgA immunoglobulin complex	ISS Inferred from Sequence or Structural Similarity more info
part_of secretory dimeric IgA immunoglobulin complex	IEA Inferred from Electronic Annotation more info
part_of secretory dimeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: immunoglobulin J chain

Names: immunoglobulin joining gene (not J region)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.