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    PTK2 protein tyrosine kinase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 506270, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PTK2provided by VGNC
    Official Full Name
    protein tyrosine kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:33518
    See related
    EnsemblRapid:ENSBTAG00070009045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FADK
    Orthologs
    human mouse all
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    Genomic context

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    See PTK2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (2844183..3037070)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 3 Neighboring gene uncharacterized LOC112449595 Neighboring gene uncharacterized LOC104973970 Neighboring gene uncharacterized LOC112449596 Neighboring gene uncharacterized LOC132342171 Neighboring gene microRNA mir-151 Neighboring gene uncharacterized LOC132342172 Neighboring gene argonaute RISC catalytic component 2 Neighboring gene chromatin accessibility complex subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants. Ali MH, et al. Am J Physiol Lung Cell Mol Physiol, 2006 Jul. PMID 16510472
    2. XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK. Ahn S, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20655298
    3. Thrombospondin-1-induced migration is functionally dependent upon focal adhesion kinase. Wang XJ, et al. Vasc Endovascular Surg, 2008 Jun-Jul. PMID 18319354
    4. RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress. Liu B, et al. Sci Rep, 2014 Nov 12. PMID 25387906, Free PMC Article
    5. Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. Lee YH, et al. Am J Respir Cell Mol Biol, 2007 Oct. PMID 17585111, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.
      Title: RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.
    2. XIAP plays an essential role in shear stress-stimulated FAK phosphorylation.
      Title: XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK.
    3. Results suggest focal adhesion kinase is involved in thrombospondin-1-induced vascular smooth muscle cell migration.
      Title: Thrombospondin-1-induced migration is functionally dependent upon focal adhesion kinase.
    4. These results suggest that TGF-beta1-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src-dependent and -independent pathways.
      Title: Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src.
    5. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C
      Title: Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    focal adhesion kinase 1
    Names
    PTK2 protein tyrosine kinase 2
    focal adhesion kinase
    NP_001068718.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075250.2 → NP_001068718.2  focal adhesion kinase 1

      Status: VALIDATED

      Source sequence(s)
      AAFC03007215, AAFC03007216, AAFC03007217, AAFC03007218, AAFC03007220, AAFC03077909, AAFC03116478, AAFC03124847, EH148384
      UniProtKB/TrEMBL
      F1MS29
      Related
      ENSBTAP00070012187.1, ENSBTAT00070020657.1
      Conserved Domains (6) summary
      cd05056
      Location:415 → 693
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143 → 248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:925 → 1054
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:422 → 685
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      2844183..3037070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials