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    ARHGEF25 Rho guanine nucleotide exchange factor 25 [ Bos taurus (domestic cattle) ]

    Gene ID: 506075, updated on 1-Jan-2025

    Summary

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    Official Symbol
    ARHGEF25provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 25provided by VGNC
    Primary source
    VGNC:VGNC:26112
    See related
    BGD:BT15763; Ensembl:ENSBTAG00000018003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GEFT
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF25 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (55872522..55879741, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 1 Neighboring gene solute carrier family 26 member 10 Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 25
    Names
    RAC/CDC42 exchange factor
    Rho guanine nucleotide exchange factor (GEF) 25
    RhoA/RAC/CDC42 exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024481.2 → NP_001019652.2  rho guanine nucleotide exchange factor 25

      See identical proteins and their annotated locations for NP_001019652.2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      A0A3Q1LKU4, F1MWU7
      Related
      ENSBTAP00000023960.5, ENSBTAT00000023960.7
      Conserved Domains (2) summary
      cd13241
      Location:378 → 520
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203 → 373
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      55872522..55879741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015471073.3 → XP_015326559.1  rho guanine nucleotide exchange factor 25 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MR77, Q5EAB1
      Conserved Domains (2) summary
      cd13241
      Location:233 → 375
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:58 → 228
      RhoGEF; RhoGEF domain

    2. XM_059886192.1 → XP_059742175.1  rho guanine nucleotide exchange factor 25 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MR77, A0A3Q1N6F4
      Related
      ENSBTAP00000066043.2, ENSBTAT00000072165.2

    3. XM_059886193.1 → XP_059742176.1  rho guanine nucleotide exchange factor 25 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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