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    LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase [ Bos taurus (domestic cattle) ]

    Gene ID: 534183, updated on 30-Jan-2025

    Summary

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    Official Symbol
    LHPPprovided by VGNC
    Official Full Name
    phospholysine phosphohistidine inorganic pyrophosphate phosphataseprovided by VGNC
    Primary source
    VGNC:VGNC:30870
    See related
    EnsemblRapid:ENSBTAG00070024913
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LHPP in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (44097549..44224863)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343976 Neighboring gene ornithine aminotransferase Neighboring gene NK1 homeobox 2 Neighboring gene uncharacterized LOC132343977 Neighboring gene family with sequence similarity 53 member B Neighboring gene EEF1A lysine methyltransferase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. 3-phosphohistidine and 6-phospholysine are substrates of a 56-kDa inorganic pyrophosphatase from bovine liver. Hiraishi H, et al. Arch Biochem Biophys, 1998 Jan 15. PMID 9448729
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    NP_001074381.1
    XP_024841482.1
    XP_024841483.1
    XP_059737889.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080912.1 → NP_001074381.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase

      See identical proteins and their annotated locations for NP_001074381.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119882
      UniProtKB/Swiss-Prot
      Q0VD18
      UniProtKB/TrEMBL
      A0AAA9TYR6
      Related
      ENSBTAP00070033817.1, ENSBTAT00070056460.1
      Conserved Domains (3) summary
      TIGR01458
      Location:11 → 267
      HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458
      pfam13242
      Location:186 → 260
      Hydrolase_like; HAD-hyrolase-like
      pfam13344
      Location:14 → 111
      Hydrolase_6; Haloacid dehalogenase-like hydrolase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44097549..44224863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024985714.2 → XP_024841482.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X2

      UniProtKB/TrEMBL
      A0AAA9SZH7, A0AAA9TYR6
      Related
      ENSBTAP00070033809.1, ENSBTAT00070056435.1
      Conserved Domains (1) summary
      cl28370
      Location:11 → 209
      NagD; Ribonucleotide monophosphatase NagD, HAD superfamily [Nucleotide transport and metabolism]

    2. XM_059881906.1 → XP_059737889.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X1

      UniProtKB/TrEMBL
      A0AAA9RUB7

    3. XM_024985715.1 → XP_024841483.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X3

      UniProtKB/TrEMBL
      A0AAA9TYR6
      Conserved Domains (1) summary
      cl28370
      Location:11 → 212
      NagD; Ribonucleotide monophosphatase NagD, HAD superfamily [Nucleotide transport and metabolism]

    RNA

    1. XR_003032731.2 RNA Sequence

      Related
      ENSBTAT00070056324.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VD18.1 GenPept UniProtKB/Swiss-Prot:Q0VD18

    Gene LinkOut

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