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    GNG2 G protein subunit gamma 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281203, updated on 30-Jan-2025

    Summary

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    Official Symbol
    GNG2provided by VGNC
    Official Full Name
    G protein subunit gamma 2provided by VGNC
    Primary source
    VGNC:VGNC:29465
    See related
    BGD:BT19831; EnsemblRapid:ENSBTAG00070011320
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HG3F1
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See GNG2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (44659756..44796955)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene thioredoxin related transmembrane protein 1 Neighboring gene FERM domain containing 6 Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene uncharacterized LOC101907464 Neighboring gene RNA transcription, translation and transport factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Determination of the complete covalent structure of the gamma 2 subunit of bovine brain G proteins by mass spectrometry. Wilcox MD, et al. Biochem Biophys Res Commun, 1995 Jul 17. PMID 7626050
    2. Existence of two gamma subunits of the G proteins in brain. Robishaw JD, et al. J Biol Chem, 1989 Sep 25. PMID 2506169
    3. Identification of a novel gamma-subunit from bovine brain GTP binding regulatory proteins (Gi/o). Sohma H, et al. Biochem Biophys Res Commun, 1993 Feb 15. PMID 8439334
    4. A G protein gamma subunit shares homology with ras proteins. Gautam N, et al. Science, 1989 May 26. PMID 2499046
    5. Gamma-subunits of G proteins, but not their alpha- or beta-subunits, are polyisoprenylated. Studies on post-translational modifications using in vitro translation with rabbit reticulocyte lysates. Sanford J, et al. J Biol Chem, 1991 May 25. PMID 1903391

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits
      Title: Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC137473

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Names
    g gamma-I
    guanine nucleotide binding protein (G protein), gamma 2
    heterotrimeric guanine nucleotide-binding protein 3F1
    NP_776497.1
    XP_005211711.1
    XP_024853007.1
    XP_024853008.1
    XP_024853009.1
    XP_059746176.1
    XP_059746177.1
    XP_059746178.1
    XP_059746179.1
    XP_059746181.1
    XP_059746182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174072.4 → NP_776497.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_776497.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112789
      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44659756..44796955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997239.2 → XP_024853007.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

    2. XM_024997240.2 → XP_024853008.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2

    3. XM_059890193.1 → XP_059746176.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X4

      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47

    4. XM_059890194.1 → XP_059746177.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X4

      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47
      Related
      ENSBTAP00070015230.1, ENSBTAT00070025516.1

    5. XM_059890195.1 → XP_059746178.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X4

      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47

    6. XM_059890196.1 → XP_059746179.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X4

      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47

    7. XM_059890198.1 → XP_059746181.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X4

      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47

    8. XM_005211654.5 → XP_005211711.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X4

      See identical proteins and their annotated locations for XP_005211711.1

      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    9. XM_059890199.1 → XP_059746182.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X4

      UniProtKB/Swiss-Prot
      P16874, P63212, Q2KI31, Q61013, Q9TS47

    10. XM_024997241.2 → XP_024853009.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63212.2 GenPept UniProtKB/Swiss-Prot:P63212

    Gene LinkOut

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