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    CLTC clathrin heavy chain [ Bos taurus (domestic cattle) ]

    Gene ID: 281080, updated on 30-Jan-2025

    Summary

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    Official Symbol
    CLTCprovided by VGNC
    Official Full Name
    clathrin heavy chainprovided by VGNC
    Primary source
    VGNC:VGNC:27471
    See related
    EnsemblRapid:ENSBTAG00070029919
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CLTC in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (10595559..10665492)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343002 Neighboring gene DEAH-box helicase 40 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene vacuole membrane protein 1 Neighboring gene microRNA mir-21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Entry of bovine parainfluenza virus type 3 into MDBK cells occurs via clathrin-mediated endocytosis and macropinocytosis in a acid-dependent manner. Pan W, et al. Vet Microbiol, 2021 Aug. PMID 34147763
    2. Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain. Zhuo Y, et al. Biochemistry, 2015 Apr 28. PMID 25844500, Free PMC Article
    3. AFM visualization of clathrin triskelia under fluid and in air. Kotova S, et al. FEBS Lett, 2010 Jan 4. PMID 19925798, Free PMC Article
    4. Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Liu SH, et al. Cell, 1995 Oct 20. PMID 7585943
    5. Two Distantly Spaced Basic Patches in the Flexible Domain of Huntingtin-Interacting Protein 1 (HIP1) Are Essential for the Binding of Clathrin Light Chain. Ybe JA, et al. Res Lett Biochem, 2009. PMID 22820750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Entry of bovine parainfluenza virus type 3 into MDBK cells occurs via clathrin-mediated endocytosis and macropinocytosis in a acid-dependent manner.
      Title: Entry of bovine parainfluenza virus type 3 into MDBK cells occurs via clathrin-mediated endocytosis and macropinocytosis in a acid-dependent manner.
    2. three different clathrin-box motif peptides can each simultaneously bind not only to the previously characterized clathrin-box site but also to the W-box site and the beta-arrestin splice loop site on a single TD.
      Title: Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain.
    3. Structure of clathrin coat with bound Hsc70 and auxilin.
      Title: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
    4. clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats
      Title: FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables clathrin light chain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of clathrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in clathrin-coated endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    clathrin heavy chain 1
    Names
    clathrin, heavy chain (Hc)
    clathrin, heavy polypeptide (Hc)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174023.2 → NP_776448.1  clathrin heavy chain 1

      See identical proteins and their annotated locations for NP_776448.1

      Status: PROVISIONAL

      Source sequence(s)
      U31757
      UniProtKB/Swiss-Prot
      P49951
      UniProtKB/TrEMBL
      A0AAA9RYT0
      Related
      ENSBTAP00070041707.1, ENSBTAT00070068253.1
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      10595559..10665492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979563.2 → XP_024835331.1  clathrin heavy chain 1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9RYT0
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam00637
      Location:1427 → 1561
      Clathrin; Region in Clathrin and VPS
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    2. XM_024979562.2 → XP_024835330.1  clathrin heavy chain 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RYT0, A0AAA9SF14
      Related
      ENSBTAP00070041765.1, ENSBTAT00070068355.1
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49951.1 GenPept UniProtKB/Swiss-Prot:P49951

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.