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    BCL2 BCL2 apoptosis regulator [ Bos taurus (domestic cattle) ]

    Gene ID: 281020, updated on 27-Dec-2024

    Summary

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    Official Symbol
    BCL2provided by VGNC
    Official Full Name
    BCL2 apoptosis regulatorprovided by VGNC
    Primary source
    VGNC:VGNC:26445
    See related
    BGD:BT11029; Ensembl:ENSBTAG00000019302
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BCL2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (61396513..61589028, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343803 Neighboring gene zinc finger CCHC-type containing 2 Neighboring gene PH domain and leucine rich repeat protein phosphatase 1 Neighboring gene uncharacterized LOC112444194 Neighboring gene U6 spliceosomal RNA Neighboring gene 3-ketodihydrosphingosine reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2. Brito PM, et al. Apoptosis, 2008 Aug. PMID 18584328
    2. BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells. Tauchi T, et al. Clin Cancer Res, 2003 Sep 15. PMID 14519654
    3. Bovine herpesvirus type 5 infection regulates Bax/BCL-2 ratio. Garcia AF, et al. Genet Mol Res, 2013 Sep 23. PMID 24085451
    4. Cloning of the bovine antiapoptotic regulator, BCL2-related protein A1, and its expression in trophoblastic binucleate cells of bovine placenta. Ushizawa K, et al. Biol Reprod, 2006 Feb. PMID 16221993
    5. RNaseCut: a MALDI mass spectrometry-based method for SNP discovery. Krebs S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655025, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
      Title: Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage.
    2. BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
      Title: Bovine herpesvirus type 5 infection regulates Bax/BCL-2 ratio.
    3. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
      Title: Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2.
    4. mRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method.
      Title: mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts.
    5. G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
      Title: BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells.
    6. role of vascular endothelial growth factor receptor-1 in Bcl-2 expression
      Title: Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.
    7. apoptosis-inducing factor was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
      Title: Functional expression of bcl-2 protein family and AIF in bovine mammary tissue in early lactation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apoptosis regulator Bcl-2
    Names
    B-cell CLL/lymphoma 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166486.1 → NP_001159958.1  apoptosis regulator Bcl-2

      See identical proteins and their annotated locations for NP_001159958.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000024
      UniProtKB/Swiss-Prot
      O02718
      UniProtKB/TrEMBL
      F6R2C4
      Related
      ENSBTAP00000025701.5, ENSBTAT00000025701.7
      Conserved Domains (1) summary
      TIGR00865
      Location:1 → 229
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      61396513..61589028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005224105.5 → XP_005224162.1  apoptosis regulator Bcl-2 isoform X1

      UniProtKB/TrEMBL
      Q8MJ81
      Conserved Domains (3) summary
      smart00265
      Location:7 → 30
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:84 → 185
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1 → 185
      bcl-2; apoptosis regulator

    2. XM_024984176.2 → XP_024839944.1  apoptosis regulator Bcl-2 isoform X2

      UniProtKB/TrEMBL
      Q8MJ81
      Conserved Domains (1) summary
      TIGR00865
      Location:1 → 185
      bcl-2; apoptosis regulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02718.1 GenPept UniProtKB/Swiss-Prot:O02718

    Gene LinkOut

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