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    AURKB aurora kinase B [ Bos taurus (domestic cattle) ]

    Gene ID: 360192, updated on 30-Jan-2025

    Summary

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    Official Symbol
    AURKBprovided by VGNC
    Official Full Name
    aurora kinase Bprovided by VGNC
    Primary source
    VGNC:VGNC:26351
    See related
    BGD:BT17075; EnsemblRapid:ENSBTAG00070018859
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    AIM-1; ARK-2; STK-1; STK12
    Orthologs
    human mouse all
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    Genomic context

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    See AURKB in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (27835751..27840837, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104975022 Neighboring gene transfer RNA isoleucine (anticodon AAU) Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene transfer RNA glycine (anticodon UCC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B. Luciano AM, et al. Biol Reprod, 2013 Mar. PMID 23325810, Free PMC Article
    2. Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development. Luciano AM, et al. Reproduction, 2010 Nov. PMID 20739377
    3. ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. Carlton JG, et al. Science, 2012 Apr 13. PMID 22422861, Free PMC Article
    4. Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation. Uzbekova S, et al. Biol Reprod, 2008 Feb. PMID 17687118
    5. ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. Thoresen SB, et al. Nat Cell Biol, 2014 Jun. PMID 24814515

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alterations in PGRMC1 and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
      Title: Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.
    2. AURKB associated with metaphase chromosomes.
      Title: Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC142782

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromosome passenger complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in spindle midzone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in spindle pole centrosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aurora kinase B
    Names
    aurora 1
    aurora- and IPL1-like midbody-associated protein 1
    aurora-B
    aurora-related kinase 2
    aurora/IPL1-related kinase 2
    serine/threonine kinase 12
    serine/threonine-protein kinase 12
    serine/threonine-protein kinase 5
    serine/threonine-protein kinase aurora-B
    NP_898907.2
    XP_005220363.1
    XP_010814291.1
    XP_010814292.1
    XP_015314161.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183084.2 → NP_898907.2  aurora kinase B

      See identical proteins and their annotated locations for NP_898907.2

      Status: PROVISIONAL

      Source sequence(s)
      BC123650
      UniProtKB/Swiss-Prot
      Q7YRC6
      UniProtKB/TrEMBL
      Q08DN4
      Related
      ENSBTAP00070025493.1, ENSBTAT00070042687.1
      Conserved Domains (1) summary
      cd14117
      Location:70 → 339
      STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27835751..27840837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010815989.4 → XP_010814291.1  aurora kinase B isoform X1

      See identical proteins and their annotated locations for XP_010814291.1

      UniProtKB/Swiss-Prot
      Q7YRC6
      UniProtKB/TrEMBL
      Q08DN4
      Conserved Domains (1) summary
      cd14117
      Location:70 → 339
      STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

    2. XM_010815990.4 → XP_010814292.1  aurora kinase B isoform X2

      See identical proteins and their annotated locations for XP_010814292.1

      UniProtKB/TrEMBL
      F6QLP7
      Related
      ENSBTAP00070025470.1, ENSBTAT00070042657.1
      Conserved Domains (1) summary
      cd14117
      Location:29 → 298
      STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

    3. XM_005220306.5 → XP_005220363.1  aurora kinase B isoform X1

      See identical proteins and their annotated locations for XP_005220363.1

      UniProtKB/Swiss-Prot
      Q7YRC6
      UniProtKB/TrEMBL
      Q08DN4
      Related
      ENSBTAP00070025489.1, ENSBTAT00070042680.1
      Conserved Domains (1) summary
      cd14117
      Location:70 → 339
      STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

    4. XM_015458675.2 → XP_015314161.1  aurora kinase B isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:21 → 187
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YRC6.1 GenPept UniProtKB/Swiss-Prot:Q7YRC6

    Gene LinkOut

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