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    DTNB dystrobrevin beta [ Bos taurus (domestic cattle) ]

    Gene ID: 534119, updated on 30-Jan-2025

    Summary

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    Official Symbol
    DTNBprovided by VGNC
    Official Full Name
    dystrobrevin betaprovided by VGNC
    Primary source
    VGNC:VGNC:28232
    See related
    BGD:BT27725; EnsemblRapid:ENSBTAG00070027185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DTNB in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (73701664..73943416)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein uS8-like Neighboring gene ASXL transcriptional regulator 2 Neighboring gene uncharacterized LOC100847382 Neighboring gene uncharacterized LOC104973427 Neighboring gene basic proline-rich protein-like Neighboring gene DNA methyltransferase 3 alpha Neighboring gene microRNA mir-1301

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synaptic signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystrobrevin beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192800.1 → NP_001179729.1  dystrobrevin beta

      See identical proteins and their annotated locations for NP_001179729.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000011
      UniProtKB/TrEMBL
      A0A3Q1LM73, E1BJB8
      Related
      ENSBTAP00070036849.1, ENSBTAT00070061880.1
      Conserved Domains (3) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54 → 214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
      cl25917
      Location:346 → 518
      Exonuc_VII_L; Exonuclease VII, large subunit

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      73701664..73943416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005213006.5 → XP_005213063.1  dystrobrevin beta isoform X2

      UniProtKB/TrEMBL
      A0A3Q1NJV0
      Conserved Domains (3) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54 → 214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
      cl25917
      Location:346 → 518
      Exonuc_VII_L; Exonuclease VII, large subunit

    2. XM_059891335.1 → XP_059747318.1  dystrobrevin beta isoform X6

      UniProtKB/TrEMBL
      A0A3Q1LM73
      Related
      ENSBTAP00070036914.1, ENSBTAT00070061967.1

    3. XM_024998836.2 → XP_024854604.1  dystrobrevin beta isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LM73, A0A3Q1M3J9
      Related
      ENSBTAP00070036880.1, ENSBTAT00070061921.1
      Conserved Domains (3) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54 → 214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
      cl25917
      Location:346 → 518
      Exonuc_VII_L; Exonuclease VII, large subunit

    4. XM_010810228.4 → XP_010808530.1  dystrobrevin beta isoform X10

      UniProtKB/TrEMBL
      A0A3Q1LM73
      Related
      ENSBTAP00070036895.1, ENSBTAT00070061941.1
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand
      cl23720
      Location:442 → 531
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. XM_059891334.1 → XP_059747317.1  dystrobrevin beta isoform X5

      UniProtKB/TrEMBL
      A0A3Q1M0J0

    6. XM_059891336.1 → XP_059747319.1  dystrobrevin beta isoform X8

      UniProtKB/TrEMBL
      A0A3Q1LM73

    7. XM_010810229.4 → XP_010808531.1  dystrobrevin beta isoform X11

      UniProtKB/TrEMBL
      A0A3Q1LM73
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand
      cl23720
      Location:412 → 501
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    8. XM_024998838.2 → XP_024854606.1  dystrobrevin beta isoform X9

      UniProtKB/TrEMBL
      A0A3Q1LFS8, A0A3Q1M0J0
      Related
      ENSBTAP00070036864.1, ENSBTAT00070061902.1
      Conserved Domains (3) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54 → 214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
      cl27210
      Location:397 → 491
      Mnd1; Mnd1 family

    9. XM_010810230.4 → XP_010808532.1  dystrobrevin beta isoform X12

      UniProtKB/TrEMBL
      A0A3Q1M0J0
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand
      pfam13874
      Location:404 → 489
      Nup54; Nucleoporin complex subunit 54

    10. XM_059891331.1 → XP_059747314.1  dystrobrevin beta isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LT95, A0A3Q1NJV0
      Related
      ENSBTAP00070036747.1, ENSBTAT00070061730.1

    11. XM_059891332.1 → XP_059747315.1  dystrobrevin beta isoform X3

      UniProtKB/TrEMBL
      A0A3Q1NJV0

    12. XM_059891333.1 → XP_059747316.1  dystrobrevin beta isoform X4

      UniProtKB/TrEMBL
      A0A3Q1NJV0

    13. XM_024998840.2 → XP_024854608.1  dystrobrevin beta isoform X13

      Conserved Domains (2) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16244
      Location:54 → 214
      EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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