GHRL ghrelin and obestatin prepropeptide [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GHRLprovided by VGNC
Official Full Name: ghrelin and obestatin prepropeptideprovided by VGNC
Primary source: VGNC:VGNC:29351
See related: BGD:BT12441; Ensembl:ENSBTAG00000012328
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: Gh1-1; ghrelin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (54313125..54317206, complement)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acyl modifications in bovine, porcine, and equine ghrelins.
Title: Acyl modifications in bovine, porcine, and equine ghrelins.
Age, gestational and heat stress effects on ghrelin secretion in dairy cattle.
Title: Age, gestational and heat stress effects on ghrelin secretion in dairy cattle.
GHRL is an important candidate gene that may be used to identify genetic variations that influence traits of economic importance in beef cattle
Title: Polymorphisms in the GHRL gene and their associations with traits of economic interest in beef cattle.
It is involved both in the short-term regulation of feeding and in the long-term regulation of energy metabolisms which may affect growth and development of the neonate.
Title: Leptin and ghrelin levels in colostrum, milk and blood plasma of sows and pig neonates during the first week of lactation.
Single nucleotide polymorphisms identified in the promoter region of the ghrelin gene could cause changes in the putative transcription factor binding sites.
Title: Effects of ghrelin gene genotypes on the growth traits in Chinese cattle.
The effects of dietary energy on the metabolism of ghrelin, leptin and growth hormone secretagogue receptor in blood and tissues of steers are reported.
Title: Circulating ghrelin and leptin concentrations and growth hormone secretagogue receptor abundance in liver, muscle, and adipose tissue of beef cattle exhibiting differences in composition of gain.
The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported.
Title: Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle.
ghrelin declined after glucose infusion and before the insulin peak; post-nadir surge in ghrelin may be regulated by the decline in circulating concentrations of glucose and nonesterified fatty acids
Title: Short communication: change in plasma ghrelin in dairy cows following an intravenous glucose challenge.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ghrelin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth hormone-releasing hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in gastric acid secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of growth hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of response to food	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: appetite-regulating hormone

Names: ghrelin/obestatin preprohormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174067.2 → NP_776492.1 appetite-regulating hormone precursor

See identical proteins and their annotated locations for NP_776492.1

Status: PROVISIONAL

Source sequence(s)

AF350329

UniProtKB/Swiss-Prot

Q0VH85, Q9BDJ6, Q9GKY6

UniProtKB/TrEMBL

B9DQV0

Related

ENSBTAP00000016350.4, ENSBTAT00000016350.5

Conserved Domains (2) summary

pfam04643
Location:56 → 114

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 50

Motilin_ghrelin; Motilin/ghrelin