Rgs14 regulator of G-protein signaling 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs14provided by MGI
Official Full Name: regulator of G-protein signaling 14provided by MGI
Primary source: MGI:MGI:1859709
See related: Ensembl:ENSMUSG00000052087 AllianceGenome:MGI:1859709
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RPIP1
Summary: Enables GTPase activating protein binding activity and GTPase activator activity. Involved in several processes, including learning or memory; negative regulation of signal transduction; and regulation of synaptic plasticity. Acts upstream of or within mitotic cell cycle. Located in several cellular components, including dendritic spine; microtubule cytoskeleton; and nuclear body. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including cochlea; neural ectoderm; and placenta. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 63.5), spleen adult (RPKM 29.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 29.8 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55517269..55532504)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55369732..55384687)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
Title: Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus.
Title: RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus.
Exercise enhancement by RGS14 disruption is mediated by brown adipose tissue.
Title: Exercise enhancement by RGS14 disruption is mediated by brown adipose tissue.
Regulator of G-protein signaling 14 protects the liver from ischemia-reperfusion injury by suppressing TGF-beta-activated kinase 1 activation.
Title: Regulator of G-protein signaling 14 protects the liver from ischemia-reperfusion injury by suppressing TGF-β-activated kinase 1 activation.
RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures.
Title: RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures.
We identified over 100 proteins with robustly enriched expression in area CA2 compared to CA1. Many of these proteins, including RGS14 and NECAB2, have already been shown to be enriched in CA2 and important for its function, while many more merit further study in the context of enhanced expression in this enigmatic brain region.
Title: Specific Proteomes of Hippocampal Regions CA2 and CA1 Reveal Proteins Linked to the Unique Physiology of Area CA2.
The disruption of RGS14 is a model of healthful aging, as it not only enhances lifespan, but also protects against obesity and cold exposure and improves metabolism with a key mechanism of increased BAT, which, when removed, eliminates the features of healthful aging.
Title: Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.
demonstrate that RGS14 is a novel CaM effector and CaMKII phosphorylation substrate thereby providing new insight into mechanisms by which RGS14 controls plasticity in CA2 neurons.
Title: Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner.
The studies results demonstrate for the first time that RGS14 regulates plasticity in hippocampal area CA2 by restricting Ca(2+) elevations in CA2 spines and downstream signaling pathways.
Title: RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling.
Study shows that RGS14 mRNA and protein are upregulated throughout postnatal mouse development, and RGS14 protein exhibits a dynamic localization pattern that is enriched in hippocampus and primary olfactory cortex in the adult mouse brain
Title: Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables GDP-dissociation inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	ISO Inferred from Sequence Orthology more info
involved_in cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in zygote asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: regulator of G-protein signaling 14

Names: RAP1/RAP2-interacting protein; rap1/rap2 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360714.1 → NP_001347643.1 regulator of G-protein signaling 14 isoform 2

Status: VALIDATED

Source sequence(s)

CT009762

Conserved Domains (3) summary

cd08743
Location:58 → 186

RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein

cd17137
Location:303 → 373

RBD1_RGS14; Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14)

cd17139
Location:374 → 446

RBD2_RGS14; Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14)
NM_016758.3 → NP_058038.2 regulator of G-protein signaling 14 isoform 1

See identical proteins and their annotated locations for NP_058038.2

Status: VALIDATED

Source sequence(s)

CT009762

Consensus CDS

CCDS36674.1

UniProtKB/Swiss-Prot

P97492, Q8K2R4, Q9DCD1

Related

ENSMUSP00000068731.8, ENSMUST00000063771.14

Conserved Domains (4) summary

cd01817
Location:304 → 377

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08743
Location:58 → 186

RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein

smart00390
Location:500 → 522

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cl00155
Location:385 → 445

UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

55517269..55532504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158089.1 → XP_036013982.1 regulator of G-protein signaling 14 isoform X1

Conserved Domains (3) summary

cd08743
Location:58 → 186

RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein

cd17137
Location:303 → 373

RBD1_RGS14; Ras-binding domain (RBD) 1 of regulator of G protein signaling 14 (RGS14)

cd17139
Location:374 → 446

RBD2_RGS14; Ras-binding domain (RBD) 2 of regulator of G protein signaling 14 (RGS14)