Znfx1 zinc finger, NFX1-type containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Znfx1provided by MGI
Official Full Name: zinc finger, NFX1-type containing 1provided by MGI
Primary source: MGI:MGI:2138982
See related: Ensembl:ENSMUSG00000039501 AllianceGenome:MGI:2138982
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Astx3
Summary: Enables RNA binding activity. Involved in activation of innate immune response; defense response to virus; and negative regulation of viral genome replication. Is active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 12.8), genital fat pad adult (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.22 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (166877713..166904926, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (167035790..167063015, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA.
Title: ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA.
ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function.
Title: ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function.
Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Title: Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear RNA-directed RNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NFX1-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033196.3 → NP_001028368.2 NFX1-type zinc finger-containing protein 1 isoform a

See identical proteins and their annotated locations for NP_001028368.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AL591711

Consensus CDS

CCDS38337.1

UniProtKB/Swiss-Prot

A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151

Related

ENSMUSP00000049404.8, ENSMUST00000048988.14

Conserved Domains (6) summary

cd06008
Location:1453 → 1497

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

PRK03918
Location:1597 → 1808

PRK03918; DNA double-strand break repair ATPase Rad50

cd18808
Location:1068 → 1244

SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases

cd17936
Location:971 → 1066

EEXXEc_NFX1; EEXXE-box helicase domain of NFX1

pfam01500
Location:1425 → 1563

Keratin_B2; Keratin, high sulfur B2 protein

pfam13086
Location:897 → 1031

AAA_11; AAA domain
NM_001291162.2 → NP_001278091.1 NFX1-type zinc finger-containing protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AL591711

Consensus CDS

CCDS71198.1

UniProtKB/TrEMBL

A2A5R6

Related

ENSMUSP00000072867.6, ENSMUST00000067584.7

Conserved Domains (4) summary

cd06008
Location:589 → 633

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

COG1112
Location:63 → 383

DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]

pfam15042
Location:626 → 690

LELP1; Late cornified envelope-like proline-rich protein 1

cl22977
Location:180 → 363

UvrD_C_2; UvrD-like helicase C-terminal domain
NM_001424669.1 → NP_001411598.1 NFX1-type zinc finger-containing protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AL591711

UniProtKB/Swiss-Prot

A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151
NM_001424676.1 → NP_001411605.1 NFX1-type zinc finger-containing protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AL591711

UniProtKB/Swiss-Prot

A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151