Uso1 USO1 vesicle docking factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uso1provided by MGI
Official Full Name: USO1 vesicle docking factorprovided by MGI
Primary source: MGI:MGI:1929095
See related: Ensembl:ENSMUSG00000029407 AllianceGenome:MGI:1929095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TAP; Vdp; 115kDa
Summary: Acts upstream of or within several processes, including Golgi organization; regulation of cellular response to insulin stimulus; and small GTPase-mediated signal transduction. Located in cytosol and perinuclear region of cytoplasm. Is expressed in central nervous system and retina. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 26.6), genital fat pad adult (RPKM 19.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E2; 5 46.05 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (92285770..92350659)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (92137909..92202800)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

knockdown of GM130 (also known as GOLGA2) or p115 (also known as USO1), two regulators of the early secretory pathway, impairs GC and ERES reorganisation. This in turn results in inhibition of myotube fusion and M-cadherin (also known as CDH15) transport to the sarcolemma.
Title: GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.
USO1 deficiency results in Golgi disruption and early embryonic lethality in mice.
Title: Golgi disruption and early embryonic lethality in mice lacking USO1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46891 (e-PCR)
- UniSTS:2380

RH140889 (e-PCR)
- UniSTS:222905

NoName (e-PCR)
- UniSTS:235220

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within secretory granule localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in transcytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcytosis	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion with Golgi apparatus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in Golgi stack	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: general vesicular transport factor p115

Names: USO1 homolog, vesicle docking protein; protein USO1 homolog; transcytosis associated protein p115; transcytosis-associated protein; vesicle docking protein, 115 kDa; vesicle-docking protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417623.1 → NP_001404552.1 general vesicular transport factor p115 isoform 1

Status: VALIDATED

Source sequence(s)

AC122438, AC125542
NM_001417624.1 → NP_001404553.1 general vesicular transport factor p115 isoform 3

Status: VALIDATED

Source sequence(s)

AC122438, AC125542
NM_001417625.1 → NP_001404554.1 general vesicular transport factor p115 isoform 4

Status: VALIDATED

Source sequence(s)

AC122438, AC125542
NM_001417626.1 → NP_001404555.1 general vesicular transport factor p115 isoform 5

Status: VALIDATED

Source sequence(s)

AC122438, AC125542
NM_001417627.1 → NP_001404556.1 general vesicular transport factor p115 isoform 6

Status: VALIDATED

Source sequence(s)

AC122438, AC125542

Related

ENSMUSP00000144592.2, ENSMUST00000202155.2
NM_001417628.1 → NP_001404557.1 general vesicular transport factor p115 isoform 7

Status: VALIDATED

Source sequence(s)

AC122438, AC125542
NM_019490.2 → NP_062363.1 general vesicular transport factor p115 isoform 2

See identical proteins and their annotated locations for NP_062363.1

Status: VALIDATED

Source sequence(s)

AC122438, AC125542

Consensus CDS

CCDS39150.1

UniProtKB/Swiss-Prot

Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5, Q9Z1Z0

Related

ENSMUSP00000031355.7, ENSMUST00000031355.10

Conserved Domains (3) summary

cd00020
Location:19 → 153

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam04869
Location:347 → 628

Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region

pfam04871
Location:841 → 934

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

92285770..92350659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535141.5 → XP_006535204.1 general vesicular transport factor p115 isoform X2

Conserved Domains (3) summary

COG1196
Location:652 → 906

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam04869
Location:347 → 635

Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region

pfam18770
Location:269 → 329

Arm_vescicular; Armadillo tether-repeat of vescicular transport factor
XM_036165322.1 → XP_036021215.1 general vesicular transport factor p115 isoform X4

Conserved Domains (3) summary

COG1196
Location:487 → 774

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam04869
Location:182 → 470

Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region

pfam18770
Location:105 → 164

Arm_vescicular; Armadillo tether-repeat of vescicular transport factor