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    Ciao2a cytosolic iron-sulfur assembly component 2A [ Mus musculus (house mouse) ]

    Gene ID: 68250, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ciao2aprovided by MGI
    Official Full Name
    cytosolic iron-sulfur assembly component 2Aprovided by MGI
    Primary source
    MGI:MGI:1915500
    See related
    Ensembl:ENSMUSG00000032381 AllianceGenome:MGI:1915500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam96a; 5730536A07Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is expressed in liver. Orthologous to human CIAO2A (cytosolic iron-sulfur assembly component 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 28.8), liver E14.5 (RPKM 23.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ciao2a in Genome Data Viewer
    Location:
    9 C; 9 35.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66033878..66046250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66126596..66138968)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6757 Neighboring gene STARR-positive B cell enhancer ABC_E11412 Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 22 Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene sorting nexin 1 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65974328-65974632 Neighboring gene death-associated protein kinase 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66059936-66060237 Neighboring gene ribosomal protein S27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice. Liu Z, et al. Free Radic Biol Med, 2022 Nov 1. PMID 36150559
    2. FAM96A knock-out promotes alternative macrophage polarization and protects mice against sepsis. Yin A, et al. Clin Exp Immunol, 2021 Mar. PMID 33232517, Free PMC Article
    3. FAM96A Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Preventing Microbial Dysbiosis. Yin A, et al. Front Cell Infect Microbiol, 2019. PMID 31803631, Free PMC Article
    4. Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism. Liu Z, et al. PLoS Negl Trop Dis, 2024 May. PMID 38713713, Free PMC Article
    5. The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. Chen KE, et al. Acta Crystallogr D Biol Crystallogr, 2012 Jun. PMID 22683786

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism.
      Title: Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism.
    2. FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice.
      Title: FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice.
    3. FAM96A knock-out promotes alternative macrophage polarization and protects mice against sepsis.
      Title: FAM96A knock-out promotes alternative macrophage polarization and protects mice against sepsis.
    4. putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein
      Title: The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic iron-sulfur assembly component 2A
    Names
    MIP18 family protein FAM96A
    family with sequence similarity 96, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359210.1 → NP_001346139.1  cytosolic iron-sulfur assembly component 2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112676, AC124439
      Conserved Domains (1) summary
      cl00941
      Location:39 → 96
      DUF59; Domain of unknown function DUF59

    2. NM_026635.3 → NP_080911.1  cytosolic iron-sulfur assembly component 2A isoform 1

      See identical proteins and their annotated locations for NP_080911.1

      Status: VALIDATED

      Source sequence(s)
      AK077700, BE655498
      Consensus CDS
      CCDS23302.1
      UniProtKB/Swiss-Prot
      Q3TD02, Q9D171, Q9DCL2
      Related
      ENSMUSP00000034945.6, ENSMUST00000034945.6
      Conserved Domains (1) summary
      cl00941
      Location:39 → 156
      FeS_assembly_P; Iron-sulfur cluster assembly protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66033878..66046250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242805.2 → XP_011241107.1  cytosolic iron-sulfur assembly component 2A isoform X2

      Conserved Domains (1) summary
      cl00941
      Location:39 → 124
      FeS_assembly_P; Iron-sulfur cluster assembly protein

    2. XM_036155224.1 → XP_036011117.1  cytosolic iron-sulfur assembly component 2A isoform X1

      Conserved Domains (1) summary
      cl00941
      Location:81 → 142
      FeS_assembly_P; Iron-sulfur cluster assembly protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCL2.1 GenPept UniProtKB/Swiss-Prot:Q9DCL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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