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    Gp9 glycoprotein 9 platelet [ Mus musculus (house mouse) ]

    Gene ID: 54368, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gp9provided by MGI
    Official Full Name
    glycoprotein 9 plateletprovided by MGI
    Primary source
    MGI:MGI:1860137
    See related
    Ensembl:ENSMUSG00000030054 AllianceGenome:MGI:1860137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd42; GPIX
    Summary
    Involved in blood coagulation and megakaryocyte development. Predicted to be part of glycoprotein Ib-IX-V complex. Is expressed in several structures, including brain; foregut; hemolymphoid system; liver; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP9 (glycoprotein IX platelet). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 11.3), liver E14.5 (RPKM 10.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gp9 in Genome Data Viewer
    Location:
    6 D1; 6 39.13 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87753115..87756768)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87776131..87779786)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene EF hand and coiled-coil domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9277 Neighboring gene predicted gene, 34414 Neighboring gene 60S ribosomal protein L3 related Neighboring gene STARR-seq mESC enhancer starr_16566 Neighboring gene RAB43, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E10388 Neighboring gene STARR-positive B cell enhancer ABC_E11324 Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene ISY1 splicing factor homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of cDNA encoding full-length mouse platelet glycoprotein IX. Kitaguchi T, et al. Blood Coagul Fibrinolysis, 1998 Jun. PMID 9690810
    2. Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Staron M, et al. Blood, 2011 Jun 30. PMID 21576699, Free PMC Article
    3. The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Delaney MK, et al. Arterioscler Thromb Vasc Biol, 2012 Nov. PMID 22995516, Free PMC Article
    4. Predominant autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia. Nishimoto T, et al. J Thromb Haemost, 2013 Feb. PMID 23176290
    5. Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome. Strassel C, et al. Haematologica, 2009 Jun. PMID 19377075, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Platelet GP Ib-IX can be considered a multifunctional participant in hemostasis, thrombosis, and the inflammatory cascade.
      Title: Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.
    2. These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia.
      Title: Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.
    3. Letter: report autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia.
      Title: Predominant autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia.
    4. A Lyn-Vav-Rac1-PI3K-Akt pathway mediates von Willebrand factor-induced activation of integrin alpha(IIb)beta(3) to promote GPIb-IX-dependent platelet activation.
      Title: The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.
    5. Data indicate that GPIX is the subunit of the glycoprotein Ib-IX-V complex that binds to grp94/Hsp90b1; the glycoprotein Ib-IX-V complex is stabilized by grp94/Hsp90b1.
      Title: Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.
    6. Findings point to a role of the GPIb-V-IX complex intrinsic to megakaryocytes at the stage of proplatelet formation and suggest a functional link with the underlying microtubular cytoskeleton in platelet biogenesis.
      Title: Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130579

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood coagulation, intrinsic pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in megakaryocyte development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of glycoprotein Ib-IX-V complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycoprotein Ib-IX-V complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet glycoprotein IX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018762.2 → NP_061232.1  platelet glycoprotein IX precursor

      See identical proteins and their annotated locations for NP_061232.1

      Status: VALIDATED

      Source sequence(s)
      AA184800, AB007464, AC158626
      Consensus CDS
      CCDS20328.1
      UniProtKB/Swiss-Prot
      O88186
      Related
      ENSMUSP00000032133.4, ENSMUST00000032133.5
      Conserved Domains (3) summary
      smart00013
      Location:19 → 53
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:46 → 76
      LRR_1; leucine-rich repeat [structural motif]
      cl15307
      Location:85 → 133
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      87753115..87756768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241410.4 → XP_011239712.1  platelet glycoprotein IX isoform X1

      See identical proteins and their annotated locations for XP_011239712.1

      Conserved Domains (4) summary
      TIGR00864
      Location:77 → 143
      PCC; polycystin cation channel protein
      smart00013
      Location:38 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:65 → 95
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:75 → 105
      LRR_8; Leucine rich repeat

    2. XM_006506394.5 → XP_006506457.1  platelet glycoprotein IX isoform X1

      See identical proteins and their annotated locations for XP_006506457.1

      Conserved Domains (4) summary
      TIGR00864
      Location:77 → 143
      PCC; polycystin cation channel protein
      smart00013
      Location:38 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:65 → 95
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:75 → 105
      LRR_8; Leucine rich repeat

    3. XM_017321682.3 → XP_017177171.1  platelet glycoprotein IX isoform X1

      Conserved Domains (4) summary
      TIGR00864
      Location:77 → 143
      PCC; polycystin cation channel protein
      smart00013
      Location:38 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:65 → 95
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:75 → 105
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88186.1 GenPept UniProtKB/Swiss-Prot:O88186

    Gene LinkOut

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