Areg amphiregulin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aregprovided by MGI
Official Full Name: amphiregulinprovided by MGI
Primary source: MGI:MGI:88068
See related: Ensembl:ENSMUSG00000029378 AllianceGenome:MGI:88068
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AR; Mcub; Sdgf
Summary: This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]
Expression: Biased expression in mammary gland adult (RPKM 59.1), duodenum adult (RPKM 26.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E2; 5 44.78 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (91287458..91296291)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (91139599..91148432)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ST2[+] Treg/amphiregulin axis protects from immune-mediated hepatitis.
Title: The ST2(+) Treg/amphiregulin axis protects from immune-mediated hepatitis.
Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse.
Title: Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse.
Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis.
Title: Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis.
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis.
Title: Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis.
Amphiregulin in infectious diseases: Role, mechanism, and potential therapeutic targets.
Title: Amphiregulin in infectious diseases: Role, mechanism, and potential therapeutic targets.
Keratinocyte-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation after Cutaneous Ischemia-Reperfusion Injury via Enhancement of Amphiregulin Production.
Title: Keratinocyte-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation after Cutaneous Ischemia-Reperfusion Injury via Enhancement of Amphiregulin Production.
The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes.
Title: The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes.
Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis.
Title: Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis.
Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension.
Title: Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension.
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Title: Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Spontaneous (1) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Areg (e-PCR), detects polymorphism
- UniSTS:516078

Areg (e-PCR), detects polymorphism
- UniSTS:233967

L41352 (e-PCR)
- UniSTS:124912

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IGI Inferred from Genetic Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-EGFR signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in glial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland alveolus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland branching involved in thelarche	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amphiregulin

Names: schwannoma-derived growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.