Tlr7 toll-like receptor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr7provided by MGI
Official Full Name: toll-like receptor 7provided by MGI
Primary source: MGI:MGI:2176882
See related: Ensembl:ENSMUSG00000044583 AllianceGenome:MGI:2176882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of macromolecule biosynthetic process; and response to virus. Acts upstream of or within positive regulation of interleukin-6 production; positive regulation of macrophage cytokine production; and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X F5; X 78.31 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (166086376..166113570, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (167303380..167330574, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production.
Title: Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production.
Rabies Virus Regulates Inflammatory Response in BV-2 Cells through Activation of Myd88 and NF-kappaB Signaling Pathways via TLR7.
Title: Rabies Virus Regulates Inflammatory Response in BV-2 Cells through Activation of Myd88 and NF-κB Signaling Pathways via TLR7.
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7.
Title: NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7.
TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice.
Title: TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice.
Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis.
Title: Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis.
TLR4/7-mediated host-defense responses of gingival epithelial cells.
Title: TLR4/7-mediated host-defense responses of gingival epithelial cells.
The Role of TLR7 and TLR9 in the Pathogenesis of Systemic Sclerosis.
Title: The Role of TLR7 and TLR9 in the Pathogenesis of Systemic Sclerosis.
Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR.
Title: Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR.
MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells.
Title: MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells.
Toll-like receptor 7 and tumor necrosis factor alpha polymorphisms in Egyptian patients with autoimmune thyroid diseases.
Title: Toll-like receptor 7 and tumor necrosis factor alpha polymorphisms in Egyptian patients with autoimmune thyroid diseases.

Submit: New GeneRIF Correction See all GeneRIFs (316)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (12) 1 citation
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXMit223 (e-PCR), detects polymorphism
- UniSTS:132113

px-71b8 (e-PCR)
- UniSTS:258160

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables siRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables single-stranded RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in response to cGMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in toll-like receptor 7 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 7 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 8 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: toll-like receptor 7

Names: Toll like receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290755.1 → NP_001277684.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_001277684.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AJ812654, AK036549, AL731735, BY543663

Consensus CDS

CCDS72469.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Related

ENSMUSP00000107787.2, ENSMUST00000112161.8

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]
NM_001290756.1 → NP_001277685.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_001277685.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AJ812654, AK036549, AL731735, BY543663

Consensus CDS

CCDS72469.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]
NM_001290757.1 → NP_001277686.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_001277686.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice site in the 5' region, and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AK036549, AL731735, BY543663

Consensus CDS

CCDS30531.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Related

ENSMUSP00000107789.2, ENSMUST00000112164.2

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]
NM_001290758.1 → NP_001277687.1 toll-like receptor 7 isoform b precursor

See identical proteins and their annotated locations for NP_001277687.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.

Source sequence(s)

AJ812652, AK036549, AL731735, BY204351, BY543663

UniProtKB/TrEMBL

U5LI18

Conserved Domains (5) summary

PRK15370
Location:35 → 246

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:757 → 841

PCC; polycystin cation channel protein

smart00255
Location:894 → 1039

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:177 → 789

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:500 → 522

LRR_RI; leucine-rich repeat [structural motif]
NM_133211.4 → NP_573474.1 toll-like receptor 7 isoform a precursor

See identical proteins and their annotated locations for NP_573474.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate exons in the 5' region and initiates translation from an alternate upstream start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).

Source sequence(s)

AK036549, AL731735, BY543663

Consensus CDS

CCDS30531.1

UniProtKB/Swiss-Prot

P58681, Q923I1

UniProtKB/TrEMBL

Q548J0, U5LI18

Related

ENSMUSP00000061853.6, ENSMUST00000060719.12

Conserved Domains (5) summary

PRK15370
Location:32 → 243

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:174 → 786

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

166086376..166113570 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528713.2 → XP_006528776.1 toll-like receptor 7 isoform X1

See identical proteins and their annotated locations for XP_006528776.1

UniProtKB/TrEMBL

U5LI18

Conserved Domains (5) summary

PRK15370
Location:35 → 246

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:757 → 841

PCC; polycystin cation channel protein

smart00255
Location:894 → 1039

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:177 → 789

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:500 → 522

LRR_RI; leucine-rich repeat [structural motif]