Swap70 SWA-70 protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Swap70provided by MGI
Official Full Name: SWA-70 proteinprovided by MGI
Primary source: MGI:MGI:1298390
See related: Ensembl:ENSMUSG00000031015 AllianceGenome:MGI:1298390
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 70kDa
Summary: Enables ATP binding activity and DNA binding activity. Involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; positive regulation of mast cell chemotaxis; and regulation of actin filament organization. Acts upstream of or within isotype switching. Located in nucleus. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 24.4), lung adult (RPKM 11.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (109820890..109882720)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (110221703..110283506)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The F-actin bundler SWAP-70 promotes tumor metastasis.
Title: The F-actin bundler SWAP-70 promotes tumor metastasis.
SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner.
Title: SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner.
Mechanism of control of F-actin cortex architecture by SWAP-70.
Title: Mechanism of control of F-actin cortex architecture by SWAP-70.
Control of GM-CSF-Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70.
Title: Control of GM-CSF-Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70.
Data support an essential and specific role for SWAP70 in tethering and stabilizing F-actin to the phagosomal surface in a wide range of phagocytes.
Title: SWAP70 is a universal GEF-like adaptor for tethering actin to phagosomes.
Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).
Title: Regulation of systemic autoimmunity and CD11c(+) Tbet(+) B cells by SWEF proteins.
findings show characteristic changes in the lipidome of CD11c+ immune cells upon their activation, and reveal an important role of SWAP-70 in the selective generation and localization of ceramides
Title: Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c(+) Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics.
DEF6 and SWAP70 are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology
Title: SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells.
SWAP-70 is not a typical oncogene, but is required for spontaneous transformation of mouse embryo fibroblasts.
Title: SWAP-70 contributes to spontaneous transformation of mouse embryo fibroblasts.
These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks.
Title: The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138692 (e-PCR)
- UniSTS:220779

AV235546 (e-PCR)
- UniSTS:165547

NoName (e-PCR)
- UniSTS:235743

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within isotype switching	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell-cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic cell DNA recombination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: switch-associated protein 70

Names: SWAP complex protein, 70 kDa; SWAP-70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417315.1 → NP_001404244.1 switch-associated protein 70 isoform 2

Status: VALIDATED

Source sequence(s)

AC124472, AC147244
NM_009302.4 → NP_033328.3 switch-associated protein 70 isoform 1

See identical proteins and their annotated locations for NP_033328.3

Status: VALIDATED

Source sequence(s)

AC124472, AC147244

Consensus CDS

CCDS21744.1

UniProtKB/Swiss-Prot

O88443, Q3TQR6, Q3UCA3, Q6A028, Q6P1D0

Related

ENSMUSP00000033325.8, ENSMUST00000033325.9

Conserved Domains (4) summary

cd13273
Location:204 → 313

PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain

pfam00169
Location:211 → 306

PH; PH domain

pfam15665
Location:316 → 527

FAM184; Family with sequence similarity 184, A and B

cl23849
Location:321 → 455

TrbI; Bacterial conjugation TrbI-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

109820890..109882720

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152861.1 → XP_036008754.1 switch-associated protein 70 isoform X1

Conserved Domains (2) summary

TIGR02168
Location:74 → 291

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:5 → 55

PH-like; Pleckstrin homology-like domain