Postn periostin, osteoblast specific factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Postnprovided by MGI
Official Full Name: periostin, osteoblast specific factorprovided by MGI
Primary source: MGI:MGI:1926321
See related: Ensembl:ENSMUSG00000027750 AllianceGenome:MGI:1926321
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PN; PLF; Osf2; OSF-2; A630052E07Rik
Summary: This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression: Biased expression in limb E14.5 (RPKM 151.8), placenta adult (RPKM 112.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 25.46 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (54266688..54298462)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (54359267..54391041)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma.
Title: The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma.
Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC.
Title: Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC.
Periostin/Bone Morphogenetic Protein 1 axis axis regulates proliferation and osteogenic differentiation of sutured mesenchymal stem cells and affects coronal suture closure in the TWIST1[+/-] mouse model of craniosynostosis.
Title: Periostin/Bone Morphogenetic Protein 1 axis axis regulates proliferation and osteogenic differentiation of sutured mesenchymal stem cells and affects coronal suture closure in the TWIST1(+/-) mouse model of craniosynostosis.
Periostin-TGF-beta feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer.
Title: Periostin-TGF-β feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer.
The comprehensive study on the role of POSTN in fetal congenital heart disease and clinical applications.
Title: The comprehensive study on the role of POSTN in fetal congenital heart disease and clinical applications.
Influence of periostin on the development of fibrocartilage layers of anterior cruciate ligament insertion.
Title: Influence of periostin on the development of fibrocartilage layers of anterior cruciate ligament insertion.
Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic beta-cell dysfunction and reducing kidney EMT.
Title: Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic β-cell dysfunction and reducing kidney EMT.
The Effect and Mechanism of POSTN and Its Alternative Splicing on the Apoptosis of Myocardial Cells in Acute Myocardial Infarction: A Study in Vitro.
Title: The Effect and Mechanism of POSTN and Its Alternative Splicing on the Apoptosis of Myocardial Cells in Acute Myocardial Infarction: A Study in Vitro.
Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.
Title: Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice.
Periostin regulates LPS-induced apoptosis via Nrf2/HO-1 pathway in periodontal ligament fibroblasts.
Title: Periostin regulates LPS-induced apoptosis via Nrf2/HO-1 pathway in periodontal ligament fibroblasts.

Submit: New GeneRIF Correction See all GeneRIFs (131)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (8) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit283 (e-PCR), detects polymorphism
- UniSTS:128636

Postn (e-PCR), detects polymorphism
- UniSTS:275848

AI747096 (e-PCR)
- UniSTS:178833

UniSTS:234679 (e-PCR)
- UniSTS:234679

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bone regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vitamin K	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vitamin K	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: periostin

Names: osteoblast specific factor 2 (fasciclin I-like); osteoblast-specific factor 2; periostin-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198765.1 → NP_001185694.1 periostin isoform 2 precursor

See identical proteins and their annotated locations for NP_001185694.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC139043, AK030756, BE850247, BF020820

Consensus CDS

CCDS57211.1

UniProtKB/TrEMBL

Q6GUA3

Related

ENSMUSP00000103619.4, ENSMUST00000107985.10

Conserved Domains (1) summary

pfam02469
Location:247 → 369

Fasciclin; Fasciclin domain
NM_001198766.1 → NP_001185695.1 periostin isoform 3 precursor

See identical proteins and their annotated locations for NP_001185695.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AC139043

Consensus CDS

CCDS57212.1

UniProtKB/TrEMBL

Q3U4U1

Related

ENSMUSP00000112735.2, ENSMUST00000117373.8

Conserved Domains (1) summary

pfam02469
Location:247 → 369

Fasciclin; Fasciclin domain
NM_001313898.1 → NP_001300827.1 periostin isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate in-frame exon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.

Source sequence(s)

AC139043

UniProtKB/TrEMBL

A0A097BW21, Q6GUA3

Conserved Domains (1) summary

pfam02469
Location:247 → 369

Fasciclin; Fasciclin domain
NM_001313899.1 → NP_001300828.1 periostin isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 5, which is shorter than isoform 1.

Source sequence(s)

AC139043

UniProtKB/TrEMBL

A0A097BW18, Q3U4U1

Conserved Domains (1) summary

pfam02469
Location:247 → 369

Fasciclin; Fasciclin domain
NM_001368678.1 → NP_001355607.1 periostin isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR and two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 6, which is longer than isoform 1.

Source sequence(s)

AC117594, AC139043

Consensus CDS

CCDS89624.1

UniProtKB/Swiss-Prot

Q62009, Q8BMJ6, Q8K1K0

UniProtKB/TrEMBL

Q6GUA3

Related

ENSMUSP00000080276.7, ENSMUST00000081564.13

Conserved Domains (1) summary

pfam02469
Location:247 → 369

Fasciclin; Fasciclin domain
NM_015784.3 → NP_056599.1 periostin isoform 1 precursor

See identical proteins and their annotated locations for NP_056599.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC139043, BE850247, BF020820, D13664

Consensus CDS

CCDS17351.1

UniProtKB/TrEMBL

Q3U4U1

Related

ENSMUSP00000072773.7, ENSMUST00000073012.13

Conserved Domains (1) summary

pfam02469
Location:247 → 369

Fasciclin; Fasciclin domain