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    Mcts1 malignant T cell amplified sequence 1 [ Mus musculus (house mouse) ]

    Gene ID: 68995, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mcts1provided by MGI
    Official Full Name
    malignant T cell amplified sequence 1provided by MGI
    Primary source
    MGI:MGI:1916245
    See related
    Ensembl:ENSMUSG00000000355 AllianceGenome:MGI:1916245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCT-1; 1500019M23Rik
    Summary
    Predicted to enable RNA cap binding activity; ribosomal small subunit binding activity; and translation factor activity, non-nucleic acid binding. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 20.4), CNS E14 (RPKM 18.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcts1 in Genome Data Viewer
    Location:
    X A3.3; X 22.88 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37653682..37702401)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38600471..38613524)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 94 pseudogene Neighboring gene predicted gene 9488 Neighboring gene cullin 4B Neighboring gene STARR-seq mESC enhancer starr_47020 Neighboring gene STARR-seq mESC enhancer starr_47021 Neighboring gene STARR-seq mESC enhancer starr_47022 Neighboring gene C1GALT1-specific chaperone 1 Neighboring gene predicted gene, 52440 Neighboring gene MAK16 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cytotoxic action of acetate on tumor cells of thymic origin: Role of MCT-1, pH homeostasis and altered cell survival regulation. Pandey SK, et al. Biochimie, 2019 Feb. PMID 30391286
    2. Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. Kwon SH, et al. J Biol Chem, 2016 Dec 2. PMID 27765817, Free PMC Article
    3. A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. Wood AJ, et al. PLoS Genet, 2007 Feb 9. PMID 17291163, Free PMC Article
    4. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Blewitt ME, et al. Nat Genet, 2008 May. PMID 18425126
    5. DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Oda M, et al. Genes Dev, 2006 Dec 15. PMID 17182866, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation factor activity, non-nucleic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRES-dependent viral translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation reinitiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    malignant T-cell-amplified sequence 1
    Names
    multiple copies T-cell malignancies 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356359.1 → NP_001343288.1  malignant T-cell-amplified sequence 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI845251, AL513356, AL845279
      Conserved Domains (2) summary
      cd11609
      Location:5 → 81
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      cd21155
      Location:81 → 176
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

    2. NM_001356360.1 → NP_001343289.1  malignant T-cell-amplified sequence 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI845251, AK138385
      Conserved Domains (2) summary
      cd11609
      Location:5 → 81
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      cd21155
      Location:81 → 176
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

    3. NM_001361381.1 → NP_001348310.1  malignant T-cell-amplified sequence 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL513356, AL845279
      Conserved Domains (2) summary
      pfam17832
      Location:5 → 38
      Pre-PUA; Pre-PUA-like domain
      cd21155
      Location:29 → 124
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

    4. NM_001361382.1 → NP_001348311.1  malignant T-cell-amplified sequence 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK138385, BC037103
      Related
      ENSMUST00000134573.2
      Conserved Domains (2) summary
      cd11609
      Location:5 → 81
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      cl00607
      Location:65 → 124
      PUA; PUA domain

    5. NM_026902.4 → NP_081178.1  malignant T-cell-amplified sequence 1 isoform 1

      See identical proteins and their annotated locations for NP_081178.1

      Status: VALIDATED

      Source sequence(s)
      AL513356, AL845279
      Consensus CDS
      CCDS30094.1
      UniProtKB/Swiss-Prot
      Q3UUI6, Q9DB27
      Related
      ENSMUSP00000000365.3, ENSMUST00000000365.3
      Conserved Domains (2) summary
      cd11609
      Location:4 → 80
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      cd21155
      Location:80 → 175
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

    RNA

    1. NR_154890.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA914196, AI845251, AL513356

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      37653682..37702401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162088.1 → XP_036017981.1  malignant T-cell-amplified sequence 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UUI6, Q9DB27
      Conserved Domains (2) summary
      cd11609
      Location:4 → 80
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      cd21155
      Location:80 → 175
      PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

    RNA

    1. XR_004940363.1 RNA Sequence

    2. XR_004940362.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB27.1 GenPept UniProtKB/Swiss-Prot:Q9DB27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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