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    Lrrc57 leucine rich repeat containing 57 [ Mus musculus (house mouse) ]

    Gene ID: 66606, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc57provided by MGI
    Official Full Name
    leucine rich repeat containing 57provided by MGI
    Primary source
    MGI:MGI:1913856
    See related
    Ensembl:ENSMUSG00000027286 AllianceGenome:MGI:1913856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810002D13Rik
    Summary
    Predicted to be located in membrane. Orthologous to human LRRC57 (leucine rich repeat containing 57). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 54.9), cortex adult (RPKM 8.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc57 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120434719..120439989, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120604238..120609508, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene STARR-seq mESC enhancer starr_05508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120308865-120309066 Neighboring gene calpain 3 Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene zinc finger protein 106 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene synaptosomal-associated protein 23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene HAUS augmin-like complex, subunit 2 Neighboring gene StAR related lipid transfer domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2 Neighboring gene STARR-seq mESC enhancer starr_05516 Neighboring gene STARR-positive B cell enhancer ABC_E3396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 57

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159609.1 → NP_001153081.1  leucine-rich repeat-containing protein 57 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK015684, BC034894, BY081522
      UniProtKB/Swiss-Prot
      Q9D1G5, Q9DC95
      Conserved Domains (2) summary
      COG4886
      Location:45 → 194
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:65 → 88
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_001159610.1 → NP_001153082.1  leucine-rich repeat-containing protein 57 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC034894, BY081522, BY293050
      UniProtKB/Swiss-Prot
      Q9D1G5, Q9DC95
      Conserved Domains (2) summary
      COG4886
      Location:62 → 211
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:82 → 105
      LRR_RI; leucine-rich repeat [structural motif]

    3. NM_001159612.1 → NP_001153084.1  leucine-rich repeat-containing protein 57 isoform c

      See identical proteins and their annotated locations for NP_001153084.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode isoform c.
      Source sequence(s)
      BC034894, CJ169080
      Consensus CDS
      CCDS16623.1
      UniProtKB/Swiss-Prot
      Q9D1G5, Q9DC95
      UniProtKB/TrEMBL
      Q8JZX5
      Related
      ENSMUSP00000099555.4, ENSMUST00000102497.10
      Conserved Domains (2) summary
      PRK15370
      Location:21 → 211
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:40 → 63
      LRR_RI; leucine-rich repeat [structural motif]

    4. NM_025657.3 → NP_079933.2  leucine-rich repeat-containing protein 57 isoform c

      See identical proteins and their annotated locations for NP_079933.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode isoform c.
      Source sequence(s)
      BC034894, BU604191
      Consensus CDS
      CCDS16623.1
      UniProtKB/Swiss-Prot
      Q9D1G5, Q9DC95
      UniProtKB/TrEMBL
      Q8JZX5
      Related
      ENSMUSP00000099554.2, ENSMUST00000102496.8
      Conserved Domains (2) summary
      PRK15370
      Location:21 → 211
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:40 → 63
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. NR_027510.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This results in a frameshift and the transcript being a candidate for nonsense-mediated mRNA decay (NMD). Therefore, it is not thought that this transcript encodes a protein.
      Source sequence(s)
      BC034894, BY081522

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120434719..120439989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500016.4 → XP_006500079.1  leucine-rich repeat-containing protein 57 isoform X1

      See identical proteins and their annotated locations for XP_006500079.1

      UniProtKB/Swiss-Prot
      Q9D1G5, Q9DC95
      UniProtKB/TrEMBL
      Q8JZX5
      Conserved Domains (2) summary
      PRK15370
      Location:21 → 211
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:40 → 63
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. XR_004940692.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1G5.1 GenPept UniProtKB/Swiss-Prot:Q9D1G5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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