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    Bri3bp Bri3 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 76809, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bri3bpprovided by MGI
    Official Full Name
    Bri3 binding proteinprovided by MGI
    Primary source
    MGI:MGI:1924059
    See related
    Ensembl:ENSMUSG00000037905 AllianceGenome:MGI:1924059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410150I18Rik
    Summary
    Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in gut; liver; lung; metanephros; and submandibular gland primordium. Orthologous to human BRI3BP (BRI3 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.3), duodenum adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bri3bp in Genome Data Viewer
    Location:
    5 G1.1; 5 64.21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125518632..125537949)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125441568..125460885)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3623 Neighboring gene nuclear encoded tRNA alanine 5 (anticodon TGC) Neighboring gene DEAH-box helicase 37 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:125921729-125921912 Neighboring gene STARR-positive B cell enhancer ABC_E853 Neighboring gene predicted gene, 40325 Neighboring gene STARR-positive B cell enhancer ABC_E6383 Neighboring gene STARR-positive B cell enhancer ABC_E6384 Neighboring gene acetoacetyl-CoA synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    2. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BRI3-binding protein
    Names
    I3-binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359486.1 → NP_001346415.1  BRI3-binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC138613
      UniProtKB/TrEMBL
      A0A0G2JGE0
      Related
      ENSMUSP00000143530.2, ENSMUST00000198811.2
      Conserved Domains (1) summary
      pfam14965
      Location:66 → 111
      BRI3BP; Negative regulator of p53/TP53

    2. NM_029752.2 → NP_084028.1  BRI3-binding protein isoform 1

      See identical proteins and their annotated locations for NP_084028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK143538, AK164638, BB618776, BY152144, CD742489
      Consensus CDS
      CCDS19686.1
      UniProtKB/Swiss-Prot
      Q8BXP1, Q8BXV2, Q9CWE5
      Related
      ENSMUSP00000037609.10, ENSMUST00000049040.14
      Conserved Domains (1) summary
      pfam14965
      Location:66 → 241
      BRI3BP; Negative regulator of p53/TP53

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      125518632..125537949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXV2.1 GenPept UniProtKB/Swiss-Prot:Q8BXV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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