Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sema3cprovided by MGI
Official Full Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Cprovided by MGI
Primary source: MGI:MGI:107557
See related: Ensembl:ENSMUSG00000028780 AllianceGenome:MGI:107557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SemE; Semae; 1110036B02Rik
Summary: Enables semaphorin receptor binding activity. Involved in several processes, including cardiac endothelial to mesenchymal transition; chordate embryonic development; and circulatory system development. Acts upstream of or within several processes, including blood vessel remodeling; dichotomous subdivision of terminal units involved in salivary gland branching; and neural crest cell migration. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and respiratory system. Orthologous to human SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 26.3), lung adult (RPKM 25.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 7.99 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (17779814..17935266)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (17574816..17730268)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.
Title: Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.
Spatial association of SEMA3C with nerve endings/terminal Schwann cells in hair follicle isthmus region.
Title: Spatial association of SEMA3C with nerve endings/terminal Schwann cells in hair follicle isthmus region.
Post-crossing CCAs switch off their response to axon guidance cues, among which the secreted Semaphorin-3C (Sema3C), that act as attractants for pre-crossing axons on their way to the midline. This change is concomitant with an upregulation of the surface protein Ephrin-B1, which acts in CCAs to inhibit Sema3C signaling via interaction with the Neuropilin-1 (Nrp1) receptor.
Title: Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons.
Taken together, epithelium-expressed SEMA3C plays a role in corneal epithelial wound closure and sensory nerve regeneration.
Title: Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy.
Sema3c is a candidate that mediates interaction between cardiac neural crest cells and the second heart field during development of the outflow tract.
Title: Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.
analyzed a complementary set of ligand-specific and tissue-specific mutants to show that neural crest-derived SEMA3C activates NRP1 in the cardiac outflow tract endothelium
Title: Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation.
Sema3A overrides the effects of Sema3C in cortical axons exposed to defined mixtures of these opposing guidance cues in vitro
Title: Integration of opposing semaphorin guidance cues in cortical axons.
No changes were observed in the binding of Sema3C to Nrp1-silenced B16(F10) cells, nor in its chemorepellent activity.
Title: The influence of neuropilin-1 silencing on semaphorin 3A and 3C activity in B16(F10) murine melanoma cells.
Data suggest that the formation and synaptic specificity of the GABAergic septohippocampal pathway relies on robust molecular mechanisms, independent of semaphorin 3C.
Title: Semaphorin 3C is not required for the establishment and target specificity of the GABAergic septohippocampal pathway in vitro.
the guidance factor Semaphorin 3C, which is expressed by corpus callosum neurons, acts through the neuropilin 1 receptor to orient axons crossing through the corpus callosum.
Title: Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sema3c (e-PCR), detects polymorphism
- UniSTS:507213

NoName (e-PCR)
- UniSTS:235133

Sema3c (e-PCR), detects polymorphism
- UniSTS:166291

D5Mit1 (e-PCR), detects polymorphism
- UniSTS:130218

Sema3c (e-PCR), detects polymorphism
- UniSTS:233938

Sema3c (e-PCR), detects polymorphism
- UniSTS:233939

Sema3c (e-PCR), detects polymorphism
- UniSTS:233940

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac endothelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac right ventricle morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb bud formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube development	IEP Inferred from Expression Pattern more info	PubMed
involved_in outflow tract morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in outflow tract septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in outflow tract septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pulmonary myocardium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somitogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: semaphorin-3C

Names: sema E; semaphorin E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013657.5 → NP_038685.3 semaphorin-3C precursor

See identical proteins and their annotated locations for NP_038685.3

Status: PROVISIONAL

Source sequence(s)

AC122936, AC161507

Consensus CDS

CCDS19099.1

UniProtKB/Swiss-Prot

Q62181, Q6NXW7

Related

ENSMUSP00000030568.8, ENSMUST00000030568.14

Conserved Domains (4) summary

cd05871
Location:575 → 664

Ig_Semaphorin_classIII; Immunoglobulin (Ig)-like domain of class III semaphorin

cd11251
Location:45 → 514

Sema_3C; The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C)

smart00410
Location:579 → 653

IG_like; Immunoglobulin like

smart00423
Location:513 → 550

PSI; domain found in Plexins, Semaphorins and Integrins