Efcab9 EF-hand calcium binding domain 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efcab9provided by MGI
Official Full Name: EF-hand calcium binding domain 9provided by MGI
Primary source: MGI:MGI:1916556
See related: Ensembl:ENSMUSG00000044056 AllianceGenome:MGI:1916556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700007I06Rik; 4930403C08Rik
Summary: Enables calcium ion binding activity and calcium ion sensor activity. Involved in flagellated sperm motility and sperm capacitation. Located in cytoplasm and sperm principal piece. Part of CatSper complex. Orthologous to human EFCAB9 (EF-hand calcium binding domain 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 38.3) and spleen adult (RPKM 1.8) See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 18.97 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (32472733..32483144, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (32522733..32533240, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion sensor activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm capacitation	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CatSper complex	IDA Inferred from Direct Assay more info	PubMed
part_of CatSper complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: EF-hand calcium-binding domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027031.3 → NP_081307.2 EF-hand calcium-binding domain-containing protein 9

See identical proteins and their annotated locations for NP_081307.2

Status: VALIDATED

Source sequence(s)

AV260313, BC087911

Consensus CDS

CCDS24528.1

UniProtKB/Swiss-Prot

Q9D5P6, Q9DAM2

Related

ENSMUSP00000060205.3, ENSMUST00000054327.3

Conserved Domains (2) summary

COG5126
Location:33 → 162

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

pfam13499
Location:108 → 162

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

32472733..32483144 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243747.4 → XP_011242049.1 EF-hand calcium-binding domain-containing protein 9 isoform X1

See identical proteins and their annotated locations for XP_011242049.1

UniProtKB/Swiss-Prot

Q9D5P6, Q9DAM2

Conserved Domains (2) summary

COG5126
Location:33 → 162

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

pfam13499
Location:108 → 162

EF-hand_7; EF-hand domain pair
XM_036156961.1 → XP_036012854.1 EF-hand calcium-binding domain-containing protein 9 isoform X2

Conserved Domains (1) summary

pfam13499
Location:43 → 97

EF-hand_7; EF-hand domain pair