Spata18 spermatogenesis associated 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spata18provided by MGI
Official Full Name: spermatogenesis associated 18provided by MGI
Primary source: MGI:MGI:1920722
See related: Ensembl:ENSMUSG00000029155 AllianceGenome:MGI:1920722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mieap; 1700067I02Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in DNA damage response; mitochondrial protein catabolic process; and mitophagy by internal vacuole formation. Predicted to be located in mitochondrion and sperm flagellum. Predicted to be active in mitochondrial outer membrane. Orthologous to human SPATA18 (spermatogenesis associated 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 188.6) See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 39.03 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (73808723..73836927)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (73651380..73679584)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer.
Title: MIEAP and ATG5 are tumor suppressors in a mouse model of BRAF(V600E)-positive thyroid cancer.
findings suggest that the Mieap-regulated mitochondrial quality control plays a critical role in preventing mouse intestinal tumorigenesis.
Title: Mieap suppresses murine intestinal tumor via its mitochondrial quality control.
DNA damage invokes mitophagy through a pathway involving Spata18.
Title: DNA damage invokes mitophagy through a pathway involving Spata18.
show that SPATA18 transcription is induced by p53 in a variety of cell types of both human and mouse origin
Title: SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cardiolipin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitophagy by internal vacuole formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy by internal vacuole formation	ISO Inferred from Sequence Orthology more info
involved_in mitophagy by internal vacuole formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiolipin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membraneless organelle	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondria-eating protein

Names: spermatogenesis associated 18 homolog; spermatogenesis-associated protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178387.3 → NP_848474.2 mitochondria-eating protein

See identical proteins and their annotated locations for NP_848474.2

Status: VALIDATED

Source sequence(s)

AC140429

Consensus CDS

CCDS57351.1

UniProtKB/Swiss-Prot

B7ZMP4, Q0P557

UniProtKB/TrEMBL

E9QAP8

Related

ENSMUSP00000064308.8, ENSMUST00000071077.14

Conserved Domains (1) summary

pfam16026
Location:296 → 484

MIEAP; Mitochondria-eating protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

73808723..73836927

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504155.3 → XP_006504218.1 mitochondria-eating protein isoform X1

UniProtKB/TrEMBL

E9QAP8

Conserved Domains (3) summary

TIGR02168
Location:118 → 238

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16026
Location:296 → 484

MIEAP; Mitochondria-eating protein

pfam12128
Location:12 → 211

DUF3584; Protein of unknown function (DUF3584)
XM_006504159.3 → XP_006504222.1 mitochondria-eating protein isoform X2

UniProtKB/TrEMBL

E9QAP8

Conserved Domains (2) summary

pfam16026
Location:264 → 452

MIEAP; Mitochondria-eating protein

pfam17045
Location:128 → 218

CEP63; Centrosomal protein of 63 kDa
XM_006504160.3 → XP_006504223.1 mitochondria-eating protein isoform X3

UniProtKB/TrEMBL

E9QAP8

Related

ENSMUSP00000040922.10, ENSMUST00000041422.15

Conserved Domains (1) summary

pfam16026
Location:264 → 452

MIEAP; Mitochondria-eating protein