Strada STE20-related kinase adaptor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stradaprovided by MGI
Official Full Name: STE20-related kinase adaptor alphaprovided by MGI
Primary source: MGI:MGI:1919399
See related: Ensembl:ENSMUSG00000069631 AllianceGenome:MGI:1919399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610019A05Rik; 6030402H20Rik; E130112C09Rik
Summary: Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to contribute to protein serine/threonine kinase activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of intracellular protein-containing complex and serine/threonine protein kinase complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular zone; cortical plate; and thymus primordium. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 47.7), frontal lobe adult (RPKM 14.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.89 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (106053739..106084460, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106162974..106193634, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle.
Title: Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle.
aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis
Title: STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI480680 (e-PCR)
- UniSTS:160176

NoName (e-PCR)
- UniSTS:236757

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
contributes_to protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect G1 to G0 transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of intracellular protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of intracellular protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of serine/threonine protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of serine/threonine protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of serine/threonine protein kinase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: STE20-related kinase adapter protein alpha

Names: STE20-related adapter protein; STRAD alpha; protein kinase LYK5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252448.2 → NP_001239377.1 STE20-related kinase adapter protein alpha isoform 1

See identical proteins and their annotated locations for NP_001239377.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL596331

Consensus CDS

CCDS56816.1

UniProtKB/Swiss-Prot

Q3UUJ4, Q6VEU7, Q9D0G8

Related

ENSMUSP00000007444.8, ENSMUST00000007444.14

Conserved Domains (1) summary

cd08227
Location:70 → 396

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
NM_001252449.2 → NP_001239378.1 STE20-related kinase adapter protein alpha isoform 3

See identical proteins and their annotated locations for NP_001239378.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two consecutive exons in the 5' coding region and a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (3) lacks a segment in the N-terminal region and a segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AL596331

UniProtKB/Swiss-Prot

Q3UUJ4

Conserved Domains (2) summary

smart00220
Location:32 → 334

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:33 → 347

PKc_like; Protein Kinases, catalytic domain
NM_028126.4 → NP_082402.1 STE20-related kinase adapter protein alpha isoform 2

See identical proteins and their annotated locations for NP_082402.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two consecutive exons in the 5' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AL596331

Consensus CDS

CCDS25550.1

UniProtKB/Swiss-Prot

Q3UUJ4

Related

ENSMUSP00000099361.4, ENSMUST00000103072.10

Conserved Domains (1) summary

cd08227
Location:33 → 359

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

106053739..106084460 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534293.4 → XP_006534356.1 STE20-related kinase adapter protein alpha isoform X2

Conserved Domains (1) summary

cd08227
Location:62 → 388

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
XM_011249270.1 → XP_011247572.1 STE20-related kinase adapter protein alpha isoform X1

See identical proteins and their annotated locations for XP_011247572.1

UniProtKB/Swiss-Prot

Q3UUJ4, Q6VEU7, Q9D0G8

Related

ENSMUST00000122989.2

Conserved Domains (1) summary

cd08227
Location:70 → 396

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
XM_006534294.5 → XP_006534357.1 STE20-related kinase adapter protein alpha isoform X3

Conserved Domains (1) summary

cd08227
Location:41 → 367

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
XM_006534297.5 → XP_006534360.1 STE20-related kinase adapter protein alpha isoform X5

See identical proteins and their annotated locations for XP_006534360.1

Conserved Domains (1) summary

cd08227
Location:13 → 339

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
XM_006534296.5 → XP_006534359.1 STE20-related kinase adapter protein alpha isoform X5

See identical proteins and their annotated locations for XP_006534359.1

Conserved Domains (1) summary

cd08227
Location:13 → 339

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
XM_006534295.3 → XP_006534358.1 STE20-related kinase adapter protein alpha isoform X4

See identical proteins and their annotated locations for XP_006534358.1

UniProtKB/Swiss-Prot

Q3UUJ4

Conserved Domains (1) summary

cd08227
Location:33 → 359

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
XM_030246360.2 → XP_030102220.1 STE20-related kinase adapter protein alpha isoform X3

Conserved Domains (1) summary

cd08227
Location:41 → 367

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha