Plxnb1 plexin B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plxnb1provided by MGI
Official Full Name: plexin B1provided by MGI
Primary source: MGI:MGI:2154238
See related: Ensembl:ENSMUSG00000053646 AllianceGenome:MGI:2154238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0407; 2900002G15Rik
Summary: Enables GTPase activating protein binding activity and semaphorin receptor activity. Involved in several processes, including negative regulation of osteoblast proliferation; nervous system development; and positive regulation of intracellular signal transduction. Acts upstream of or within positive regulation of axonogenesis. Part of semaphorin receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB1 (plexin B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 35.3), ovary adult (RPKM 25.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.63 cM

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108922915..108948983)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (109093849..109119915)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease.
Title: Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease.
Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins.
Title: Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins.
Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder.
Title: Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder.
Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models.
Title: Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models.
Inhibition of Semaphorin 4D/Plexin-B1 signaling inhibits the subchondral bone loss in early-stage osteoarthritis of the temporomandibular joint.
Title: Inhibition of Semaphorin 4D/Plexin-B1 signaling inhibits the subchondral bone loss in early-stage osteoarthritis of the temporomandibular joint.
Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy.
Title: Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy.
These results demonstrate a novel physiological function for sema4D/plxnB1 signaling in retinal pigment epithelium phagocytosis.
Title: Semaphorin4D-PlexinB1 Signaling Attenuates Photoreceptor Outer Segment Phagocytosis by Reducing Rac1 Activity of RPE Cells.
Plexin-B1 coordinates cell repolarization through RhoA-ROCK-mediated redistribution of Plexin-B1.
Title: Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts.
Plexin-B1 and -B2 play redundant or compensatory roles during forebrain development to ensure proper neuronal production and neocortical expansion.
Title: Impaired cortical neurogenesis in plexin-B1 and -B2 double deletion mutant.
Deletion of plexin-B1, the high affinity receptor for semaphorin 4D, significantly (one-way ANOVA; p < 0.001) reduced thrombus weight (- 40%) in oxidative venous thrombosis.
Title: Does plexin-B1, a semaphorin 4D receptor, play a role in thrombosis?

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plxnb1 (e-PCR), detects polymorphism
- UniSTS:546955

AU042020 (e-PCR)
- UniSTS:159921

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables semaphorin receptor activity	ISO Inferred from Sequence Orthology more info
enables semaphorin receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in inhibitory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification involved in bone maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of semaphorin receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of semaphorin receptor complex	ISO Inferred from Sequence Orthology more info
part_of semaphorin receptor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: plexin-B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172775.2 → NP_766363.2 plexin-B1 precursor

See identical proteins and their annotated locations for NP_766363.2

Status: VALIDATED

Source sequence(s)

AB072381, BC150701, CJ173103, CJ261396

Consensus CDS

CCDS23546.1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Related

ENSMUSP00000071966.7, ENSMUST00000072093.13

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

108922915..108948983

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512076.5 → XP_006512139.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_006512139.1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006512078.3 → XP_006512141.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_006512141.1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006512075.4 → XP_006512138.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_006512138.1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006512081.2 → XP_006512144.1 plexin-B1 isoform X2

Conserved Domains (6) summary

smart00423
Location:209 → 256

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:350 → 437

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:258 → 349

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam08337
Location:736 → 1275

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam18020
Location:109 → 208

TIG_2; TIG domain found in plexin

cl15674
Location:440 → 550

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_030244345.1 → XP_030100205.1 plexin-B1 isoform X1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006512079.4 → XP_006512142.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_006512142.1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_036154913.1 → XP_036010806.1 plexin-B1 isoform X1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006512080.4 → XP_006512143.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_006512143.1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006512077.5 → XP_006512140.1 plexin-B1 isoform X1

See identical proteins and their annotated locations for XP_006512140.1

UniProtKB/Swiss-Prot

E9QKS4, Q6ZQC3, Q80ZZ1, Q8CJH3

UniProtKB/TrEMBL

B2RWT9

Conserved Domains (10) summary

smart00423
Location:641 → 677

PSI; domain found in Plexins, Semaphorins and Integrins

PHA03247
Location:713 → 851

PHA03247; large tegument protein UL36; Provisional

cd01180
Location:1068 → 1159

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:481 → 527

PSI; Plexin repeat

pfam01833
Location:1362 → 1432

TIG; IPT/TIG domain

pfam08337
Location:1546 → 2086

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:541 → 627

TIG_plexin; TIG domain

pfam18020
Location:919 → 1018

TIG_2; TIG domain found in plexin

cl15674
Location:1160 → 1247

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:28 → 480

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_030244347.1 → XP_030100207.1 plexin-B1 isoform X3

Conserved Domains (4) summary

cd01179
Location:127 → 214

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:35 → 126

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam08337
Location:513 → 1053

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:217 → 327

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_030244346.1 → XP_030100206.1 plexin-B1 isoform X3

Conserved Domains (4) summary

cd01179
Location:127 → 214

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:35 → 126

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam08337
Location:513 → 1053

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:217 → 327

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
XM_036154914.1 → XP_036010807.1 plexin-B1 isoform X3

Conserved Domains (4) summary

cd01179
Location:127 → 214

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:35 → 126

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam08337
Location:513 → 1053

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:217 → 327

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...