Plcxd3 phosphatidylinositol-specific phospholipase C, X domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plcxd3provided by MGI
Official Full Name: phosphatidylinositol-specific phospholipase C, X domain containing 3provided by MGI
Primary source: MGI:MGI:2442605
See related: Ensembl:ENSMUSG00000049148 AllianceGenome:MGI:2442605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130016O10Rik
Summary: Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Is active in glutamatergic synapse. Is expressed in telencephalon. Orthologous to human PLCXD3 (phosphatidylinositol specific phospholipase C X domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 3.6), CNS E18 (RPKM 2.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 1.96 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (4404973..4605067)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (4375491..4575585)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plcxd3 is an activity dependent gene in mouse olfactory sensory neurons.
Title: Activity-dependent genes in mouse olfactory sensory neurons.
Three intronic SNPs in the PLCXD3 gene (rs319013, rs76547469, and rs545358) are associated with increased risk of CJD compared with published healthy control data and represent the first major association of a non- PRNP candidate gene.
Title: Splice site SNPs of phospholipase PLCXD3 are significantly associated with variant and sporadic Creutzfeldt-Jakob disease.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphoric diester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PI-PLC X domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.