Dcun1d3 defective in cullin neddylation 1 domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcun1d3provided by MGI
Official Full Name: defective in cullin neddylation 1 domain containing 3provided by MGI
Primary source: MGI:MGI:2679003
See related: Ensembl:ENSMUSG00000048787 AllianceGenome:MGI:2679003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DCNL3; SCCRO3; 1700020A13Rik
Summary: Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; protein neddylation; and regulation of protein neddylation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of ubiquitin ligase complex. Is expressed in central nervous system; reproductive system; and urinary system. Orthologous to human DCUN1D3 (defective in cullin neddylation 1 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 6.8), bladder adult (RPKM 2.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 64.27 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (119452381..119495553, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (119853158..119896330, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1M7Mit66 (e-PCR)
- UniSTS:131284

D7Mit66 (e-PCR), detects polymorphism
- UniSTS:131284

UniSTS:235764 (e-PCR)
- UniSTS:235764

NoName (e-PCR)
- UniSTS:235766

24.MMHAP35FRH9.seq (e-PCR)
- UniSTS:123641

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV-C	ISO Inferred from Sequence Orthology more info
involved_in response to UV-C	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in response to gamma radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DCN1-like protein 3

Names: DCN1, defective in cullin neddylation 1, domain containing 3; DCUN1 domain-containing protein 3; defective in cullin neddylation protein 1-like protein 3; squamous cell carcinoma-related oncogene 3

NP_001157175.1

EC 3.1.-.-

NP_775584.1

EC 3.1.-.-

XP_006507744.1

EC 3.1.-.-

XP_011240050.1

EC 3.1.-.-

XP_011240051.1

EC 3.1.-.-

XP_011240053.1

EC 3.1.-.-

XP_036008898.1

EC 3.1.-.-

XP_036008899.1

EC 3.1.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163703.1 → NP_001157175.1 DCN1-like protein 3

See identical proteins and their annotated locations for NP_001157175.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC122423, AC131702

Consensus CDS

CCDS21789.1

UniProtKB/Swiss-Prot

Q8K0V2

Related

ENSMUSP00000058968.7, ENSMUST00000059851.14

Conserved Domains (1) summary

pfam03556
Location:164 → 276

Cullin_binding; Cullin binding
NM_173408.3 → NP_775584.1 DCN1-like protein 3

See identical proteins and their annotated locations for NP_775584.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC122423, AC131702

Consensus CDS

CCDS21789.1

UniProtKB/Swiss-Prot

Q8K0V2

Related

ENSMUSP00000095686.3, ENSMUST00000098080.9

Conserved Domains (1) summary

pfam03556
Location:164 → 276

Cullin_binding; Cullin binding