Insyn1 inhibitory synaptic factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Insyn1provided by MGI
Official Full Name: inhibitory synaptic factor 1provided by MGI
Primary source: MGI:MGI:2442108
See related: Ensembl:ENSMUSG00000066607 AllianceGenome:MGI:2442108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6030419C18Rik
Summary: Involved in inhibitory postsynaptic potential and postsynaptic specialization organization. Located in postsynaptic density. Is active in GABA-ergic synapse and postsynaptic specialization. Orthologous to human INSYN1 (inhibitory synaptic factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 36.6), cerebellum adult (RPKM 35.6) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.79 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (58395886..58407063)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (58488603..58499780)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493188

AU016588 (e-PCR)
- UniSTS:179922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission, postsynaptic	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission, postsynaptic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibitory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in inhibitory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic specialization organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic specialization organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: inhibitory synaptic factor 1

Names: UPF0583 protein C15orf59 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.