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    Stum mechanosensory transduction mediator [ Mus musculus (house mouse) ]

    Gene ID: 381310, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stumprovided by MGI
    Official Full Name
    mechanosensory transduction mediatorprovided by MGI
    Primary source
    MGI:MGI:2138735
    See related
    Ensembl:ENSMUSG00000053963 AllianceGenome:MGI:2138735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm10001; 6330403A02Rik
    Summary
    Predicted to be located in membrane. Orthologous to human STUM (stum, mechanosensory transduction mediator homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 26.6), bladder adult (RPKM 22.8) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stum in Genome Data Viewer
    Location:
    1 H4; 1 84.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180259938..180311199, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180432373..180483519, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3341 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene inositol 1,4,5-trisphosphate 3-kinase B Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182286358-182286687 Neighboring gene STARR-positive B cell enhancer ABC_E2591 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182296519-182296775 Neighboring gene STARR-positive B cell enhancer ABC_E1575 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182331940-182332241 Neighboring gene STARR-positive B cell enhancer ABC_E5870 Neighboring gene predicted gene, 39712 Neighboring gene STARR-positive B cell enhancer ABC_E5871 Neighboring gene STARR-positive B cell enhancer ABC_E5872 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182471419-182471720 Neighboring gene STARR-positive B cell enhancer ABC_E3342 Neighboring gene predicted gene, 31986 Neighboring gene STARR-seq mESC enhancer starr_03207 Neighboring gene poly (ADP-ribose) polymerase family, member 1 Neighboring gene microRNA 6904

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The stum gene is essential for mechanical sensing in proprioceptive neurons. Desai BS, et al. Science, 2014 Mar 14. PMID 24626929
    2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
    3. Molecular architecture of the developing mouse brain. La Manno G, et al. Nature, 2021 Aug. PMID 34321664
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein stum homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081227.2 → NP_001074696.1  protein stum homolog

      See identical proteins and their annotated locations for NP_001074696.1

      Status: VALIDATED

      Source sequence(s)
      AC121838, AK031805, BY637651, DN174476
      Consensus CDS
      CCDS48467.1
      UniProtKB/Swiss-Prot
      Q0VBF8
      UniProtKB/TrEMBL
      J3QP43
      Related
      ENSMUSP00000119782.2, ENSMUST00000136521.2
      Conserved Domains (1) summary
      pfam15795
      Location:44 → 127
      Spec3; Ectodermal ciliogenesis protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180259938..180311199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496914.5 → XP_006496977.1  protein stum homolog isoform X2

      UniProtKB/TrEMBL
      J3QP43
      Conserved Domains (1) summary
      pfam15795
      Location:44 → 127
      Spec3; Ectodermal ciliogenesis protein

    2. XM_006496913.5 → XP_006496976.1  protein stum homolog isoform X1

      UniProtKB/TrEMBL
      A0A1B0GS08, J3QP43
      Related
      ENSMUSP00000147747.2, ENSMUST00000211561.2
      Conserved Domains (1) summary
      pfam15795
      Location:44 → 127
      Spec3; Ectodermal ciliogenesis protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VBF8.1 GenPept UniProtKB/Swiss-Prot:Q0VBF8

    Gene LinkOut

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