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    Bcl7c B cell CLL/lymphoma 7C [ Mus musculus (house mouse) ]

    Gene ID: 12055, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bcl7cprovided by MGI
    Official Full Name
    B cell CLL/lymphoma 7Cprovided by MGI
    Primary source
    MGI:MGI:1332237
    See related
    Ensembl:ENSMUSG00000030814 AllianceGenome:MGI:1332237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230096E12Rik
    Summary
    Predicted to be involved in apoptotic process. Part of SWI/SNF complex. Is expressed in embryo. Orthologous to human BCL7C (BAF chromatin remodeling complex subunit BCL7C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 8.6), CNS E18 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcl7c in Genome Data Viewer
    Location:
    7 F3; 7 69.65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127260626..127307938, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127661454..127708766, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51458 Neighboring gene predicted gene, 53373 Neighboring gene predicted gene, 39090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134851639-134851826 Neighboring gene microRNA 762 Neighboring gene cardiotrophin 1 Neighboring gene cardiotrophin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA interference of IL-10 in leukemic B-1 cells. McCarthy BA, et al. Cancer Immun, 2004 Jul 23. PMID 15270555
    2. The BCL7 gene family: deletion of BCL7B in Williams syndrome. Jadayel DM, et al. Gene, 1998 Dec 11. PMID 9931421
    3. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Wischhof L, et al. Sci Rep, 2017 Dec 6. PMID 29213114, Free PMC Article
    4. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Kadoch C, et al. Nat Genet, 2013 Jun. PMID 23644491, Free PMC Article
    5. BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. Wischhof L, et al. EMBO J, 2022 Dec 1. PMID 36305367, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SWI/SNF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    B-cell CLL/lymphoma 7 protein family member C
    Names
    B-cell chronic lymphocytic leukemia/lymphoma 7C protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347652.1 → NP_001334581.1  B-cell CLL/lymphoma 7 protein family member C isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124507
      Consensus CDS
      CCDS85422.1
      UniProtKB/TrEMBL
      A0A0U1RNX8
      Related
      ENSMUSP00000145743.2, ENSMUST00000205977.2

    2. NM_009746.2 → NP_033876.1  B-cell CLL/lymphoma 7 protein family member C isoform 2

      See identical proteins and their annotated locations for NP_033876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC005673
      Consensus CDS
      CCDS21874.1
      UniProtKB/Swiss-Prot
      O08664, Q99LS2
      Related
      ENSMUSP00000057937.9, ENSMUST00000061468.9
      Conserved Domains (2) summary
      PHA03249
      Location:93 → 177
      PHA03249; DNA packaging tegument protein UL25; Provisional
      pfam04714
      Location:4 → 50
      BCL_N; BCL7, N-terminal conserver region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127260626..127307938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08664.1 GenPept UniProtKB/Swiss-Prot:O08664

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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