Perm1 PPARGC1 and ESRR induced regulator, muscle 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Perm1provided by MGI
Official Full Name: PPARGC1 and ESRR induced regulator, muscle 1provided by MGI
Primary source: MGI:MGI:1921433
See related: Ensembl:ENSMUSG00000078486 AllianceGenome:MGI:1921433
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310042D19Rik
Summary: Involved in regulation of DNA-templated transcription and response to muscle activity. Located in cytoplasm and nucleus. Is expressed in gastrocnemius muscle; heart; heart atrium; and heart ventricle. Orthologous to human PERM1 (PPARGC1 and ESRR induced regulator, muscle 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 66.5), stomach adult (RPKM 6.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 88.62 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (156287724..156305766)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (156203262..156221307)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARalpha and PGC-1alpha.
Title: PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARα and PGC-1α.
PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B.
Title: PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B.
Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.
Title: Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.
ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation.
Title: ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation.
Citrus hassaku Extract Powder Increases Mitochondrial Content and Oxidative Muscle Fibers by Upregulation of PGC-1alpha in Skeletal Muscle.
Title: Citrus hassaku Extract Powder Increases Mitochondrial Content and Oxidative Muscle Fibers by Upregulation of PGC-1α in Skeletal Muscle.
Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.
Title: Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.
These findings identify Perm1 as a muscle-specific regulator of exercise-induced signaling and Perm1 levels as tuners of the skeletal muscle response to exercise.
Title: Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training.
a role for Perm1 acting downstream of PGC-1alpha and ERRs to regulate muscle-specific pathways important for energy metabolism and contractile function.
Title: Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Cdk9 (e-PCR), detects polymorphism
- UniSTS:527281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to muscle activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PGC-1 and ERR-induced regulator in muscle protein 1

Names: PGC-1 and ERR-induced regulator in muscle 1; PPARGC1 and ESRR-induced regulator in muscle 1; peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.