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    Ttll10 tubulin tyrosine ligase-like family, member 10 [ Mus musculus (house mouse) ]

    Gene ID: 330010, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttll10provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like family, member 10provided by MGI
    Primary source
    MGI:MGI:1921855
    See related
    Ensembl:ENSMUSG00000029074 AllianceGenome:MGI:1921855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttll5; 4833412E22Rik; 4930595O22Rik
    Summary
    Enables protein-glycine ligase activity, elongating. Involved in protein polyglycylation. Located in axoneme and microtubule cytoskeleton. Is expressed in white fat. Orthologous to human TTLL10 (tubulin tyrosine ligase like 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 132.3) and colon adult (RPKM 7.2) See more
    Orthologs
    human all
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    Genomic context

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    See Ttll10 in Genome Data Viewer
    Location:
    4 E2; 4 87.82 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156119292..156135274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156034835..156050817, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16008 Neighboring gene predicted gene, 25982 Neighboring gene tumor necrosis factor receptor superfamily, member 18 Neighboring gene predicted gene 13648 Neighboring gene microRNA 429 Neighboring gene microRNA 200a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TTLL10 can perform tubulin glycylation when co-expressed with TTLL8. Ikegami K, et al. FEBS Lett, 2009 Jun 18. PMID 19427864
    2. TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1. Ikegami K, et al. FEBS Lett, 2008 Apr 2. PMID 18331838, Free PMC Article
    3. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
    4. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    5. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity, elongating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glycine ligase activity, elongating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyglycylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein polyglycylase TTLL10
    Names
    tubulin tyrosine ligase-like family, member 5
    tubulin--tyrosine ligase-like protein 10
    NP_001355570.1
    NP_083540.1
    XP_036020095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368641.1 → NP_001355570.1  protein polyglycylase TTLL10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627204
      Consensus CDS
      CCDS89873.1
      UniProtKB/Swiss-Prot
      A4Q9F3, Q3V0K4
      UniProtKB/TrEMBL
      V9GXT8
      Related
      ENSMUSP00000139316.2, ENSMUST00000184348.8
      Conserved Domains (1) summary
      cl17255
      Location:272 → 525
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    2. NM_029264.2 → NP_083540.1  protein polyglycylase TTLL10 isoform 1

      See identical proteins and their annotated locations for NP_083540.1

      Status: VALIDATED

      Source sequence(s)
      AK133079
      Consensus CDS
      CCDS19058.1
      UniProtKB/Swiss-Prot
      A4Q9F3, Q3V0K4
      UniProtKB/TrEMBL
      B1ASM0
      Related
      ENSMUSP00000055671.9, ENSMUST00000051509.15
      Conserved Domains (1) summary
      cl17255
      Location:243 → 496
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156119292..156135274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164202.1 → XP_036020095.1  protein polyglycylase TTLL10 isoform X1

      Conserved Domains (1) summary
      cl17255
      Location:292 → 436
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4Q9F3.1 GenPept UniProtKB/Swiss-Prot:A4Q9F3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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