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    Cog5 component of oligomeric golgi complex 5 [ Mus musculus (house mouse) ]

    Gene ID: 238123, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cog5provided by MGI
    Official Full Name
    component of oligomeric golgi complex 5provided by MGI
    Primary source
    MGI:MGI:2145130
    See related
    Ensembl:ENSMUSG00000035933 AllianceGenome:MGI:2145130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GTC90; GOLTC1; 5430405C01Rik
    Summary
    Predicted to be involved in Golgi organization; glycosylation; and retrograde transport, vesicle recycling within Golgi. Predicted to act upstream of or within inter-Golgi cisterna vesicle-mediated transport. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIi. Orthologous to human COG5 (component of oligomeric golgi complex 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 11.7), mammary gland adult (RPKM 11.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cog5 in Genome Data Viewer
    Location:
    12 A3; 12 13.68 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31704848..31987629)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31654819..31937630)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene B cell receptor associated protein 29 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32339618-32339801 Neighboring gene STARR-seq mESC enhancer starr_31859 Neighboring gene dihydrouridine synthase 4 like Neighboring gene STARR-seq mESC enhancer starr_31862 Neighboring gene G protein-coupled receptor 22 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31865 Neighboring gene predicted gene, 25913 Neighboring gene predicted gene, 35666 Neighboring gene STARR-positive B cell enhancer ABC_E79 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32658358-32658559 Neighboring gene high mobility group box transcription factor 1 Neighboring gene protein kinase, cAMP dependent regulatory, type II beta Neighboring gene STARR-positive B cell enhancer ABC_E4024 Neighboring gene predicted gene, 53716 Neighboring gene STARR-seq mESC enhancer starr_31869 Neighboring gene predicted gene, 51992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inter-Golgi cisterna vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    conserved oligomeric Golgi complex subunit 5
    Names
    COG complex subunit 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163126.1 → NP_001156598.1  conserved oligomeric Golgi complex subunit 5

      See identical proteins and their annotated locations for NP_001156598.1

      Status: VALIDATED

      Source sequence(s)
      AK030656, BM244396, CA316530, CA580184, CX240209
      Consensus CDS
      CCDS49046.1
      UniProtKB/Swiss-Prot
      E9QM30, Q8C0L8
      Related
      ENSMUSP00000044797.5, ENSMUST00000036862.5
      Conserved Domains (1) summary
      pfam10392
      Location:35 → 158
      COG5; Golgi transport complex subunit 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      31704848..31987629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515084.5 → XP_006515147.1  conserved oligomeric Golgi complex subunit 5 isoform X2

      Conserved Domains (1) summary
      pfam10392
      Location:35 → 158
      COG5; Golgi transport complex subunit 5

    2. XM_006515083.3 → XP_006515146.1  conserved oligomeric Golgi complex subunit 5 isoform X1

      Conserved Domains (1) summary
      pfam10392
      Location:35 → 158
      COG5; Golgi transport complex subunit 5

    3. XM_017315052.3 → XP_017170541.1  conserved oligomeric Golgi complex subunit 5 isoform X3

      Conserved Domains (1) summary
      cl00549
      Location:360 → 464
      ABC_membrane; ABC transporter transmembrane region

    4. XM_011243869.4 → XP_011242171.1  conserved oligomeric Golgi complex subunit 5 isoform X3

      Conserved Domains (1) summary
      cl00549
      Location:360 → 464
      ABC_membrane; ABC transporter transmembrane region

    5. XM_017315053.3 → XP_017170542.1  conserved oligomeric Golgi complex subunit 5 isoform X4

      Conserved Domains (1) summary
      cl00549
      Location:306 → 410
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0L8.3 GenPept UniProtKB/Swiss-Prot:Q8C0L8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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