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    Mgst2 microsomal glutathione S-transferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 211666, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mgst2provided by MGI
    Official Full Name
    microsomal glutathione S-transferase 2provided by MGI
    Primary source
    MGI:MGI:2448481
    See related
    Ensembl:ENSMUSG00000074604 AllianceGenome:MGI:2448481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GST2; MGST-II
    Summary
    Predicted to enable several functions, including glutathione binding activity; glutathione peroxidase activity; and glutathione transferase activity. Predicted to be involved in glutathione biosynthetic process; leukotriene biosynthetic process; and membrane lipid catabolic process. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Orthologous to human MGST2 (microsomal glutathione S-transferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in large intestine adult (RPKM 4.2), bladder adult (RPKM 2.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mgst2 in Genome Data Viewer
    Location:
    3 C; 3 22.52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51544179..51590096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51636912..51682675)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51314972-51315081 Neighboring gene STARR-seq mESC enhancer starr_07615 Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51358072-51358308 Neighboring gene predicted gene, 36008 Neighboring gene STARR-positive B cell enhancer mm9_chr3:51363442-51363743 Neighboring gene SET domain containing (lysine methyltransferase) 7 Neighboring gene STARR-seq mESC enhancer starr_07617 Neighboring gene STARR-seq mESC enhancer starr_07618 Neighboring gene STARR-seq mESC enhancer starr_07619 Neighboring gene STARR-seq mESC enhancer starr_07620 Neighboring gene STARR-positive B cell enhancer ABC_E11183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51440808-51440917 Neighboring gene STARR-seq mESC enhancer starr_07621 Neighboring gene STARR-seq mESC enhancer starr_07622 Neighboring gene STARR-seq mESC enhancer starr_07623 Neighboring gene STARR-seq mESC enhancer starr_07624 Neighboring gene predicted gene, 38247 Neighboring gene VISTA enhancer mm1010 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51549117-51549270 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene predicted gene, 46803 Neighboring gene VISTA enhancer mm1452 Neighboring gene STARR-seq mESC enhancer starr_07625 Neighboring gene VISTA enhancer mm1388 Neighboring gene STARR-seq mESC enhancer starr_07626 Neighboring gene STARR-positive B cell enhancer ABC_E1019 Neighboring gene STARR-positive B cell enhancer ABC_E7911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51839623-51839732 Neighboring gene predicted gene, 30074

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Dvash E, et al. Nat Commun, 2015 Dec 11. PMID 26656251, Free PMC Article
    2. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury. Veniaminova NA, et al. Cell Rep, 2023 Sep 26. PMID 37715952, Free PMC Article
    3. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC41409

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables leukotriene-C4 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-C4 synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microsomal glutathione S-transferase 2
    Names
    glutathione peroxidase MGST2
    leukotriene C4 synthase MGST2
    microsomal GST-2
    microsomal GST-II
    microsomal glutathione S-transferase II
    NP_001297411.1
    NP_778160.2
    XP_006501311.1
    XP_011238358.1
    XP_011238359.1
    XP_030108387.1
    XP_030108388.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310482.1 → NP_001297411.1  microsomal glutathione S-transferase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI005961, BC145529, EH107642
      Consensus CDS
      CCDS79903.1
      UniProtKB/TrEMBL
      A0A0A6YWX7
      Related
      ENSMUSP00000141745.2, ENSMUST00000159554.7
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 72
      MAPEG; MAPEG family

    2. NM_174995.3 → NP_778160.2  microsomal glutathione S-transferase 2 isoform 1

      See identical proteins and their annotated locations for NP_778160.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA794266, AI005961, AV064608, EH107642
      Consensus CDS
      CCDS38428.1
      UniProtKB/Swiss-Prot
      A2RST1
      Related
      ENSMUSP00000096705.4, ENSMUST00000099106.10
      Conserved Domains (1) summary
      pfam01124
      Location:8 → 124
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51544179..51590096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252528.2 → XP_030108388.1  microsomal glutathione S-transferase 2 isoform X2

    2. XM_006501248.1 → XP_006501311.1  microsomal glutathione S-transferase 2 isoform X2

      See identical proteins and their annotated locations for XP_006501311.1

    3. XM_011240056.4 → XP_011238358.1  microsomal glutathione S-transferase 2 isoform X1

    4. XM_030252527.2 → XP_030108387.1  microsomal glutathione S-transferase 2 isoform X2

    5. XM_011240057.4 → XP_011238359.1  microsomal glutathione S-transferase 2 isoform X2

      See identical proteins and their annotated locations for XP_011238359.1

      Conserved Domains (1) summary
      pfam01124
      Location:1 → 58
      MAPEG; MAPEG family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RST1.1 GenPept UniProtKB/Swiss-Prot:A2RST1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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