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    B3galnt2 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 [ Mus musculus (house mouse) ]

    Gene ID: 97884, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B3galnt2provided by MGI
    Official Full Name
    UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2provided by MGI
    Primary source
    MGI:MGI:2145517
    See related
    Ensembl:ENSMUSG00000039242 AllianceGenome:MGI:2145517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930105D20Rik; D230016N13Rik
    Summary
    Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to act upstream of or within UDP-N-acetylgalactosamine metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A11. Orthologous to human B3GALNT2 (beta-1,3-N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.6), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3galnt2 in Genome Data Viewer
    Location:
    13 A1; 13 5.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (14129059..14173688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13954474..13999103)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_33706 Neighboring gene STARR-seq mESC enhancer starr_33707 Neighboring gene zinc finger and BTB domain containing 7B pseudogene Neighboring gene tubulin-specific chaperone E Neighboring gene STARR-seq mESC enhancer starr_33708 Neighboring gene STARR-positive B cell enhancer ABC_E5369 Neighboring gene STARR-positive B cell enhancer ABC_E9866 Neighboring gene STARR-positive B cell enhancer ABC_E32 Neighboring gene geranylgeranyl diphosphate synthase 1 Neighboring gene AT-rich interaction domain 4B Neighboring gene predicted gene, 26129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc. Hiruma T, et al. J Biol Chem, 2004 Apr 2. PMID 14724282
    2. SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Yoshida-Moriguchi T, et al. Science, 2013 Aug 23. PMID 23929950, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103263

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-N-acetylgalactosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
    Names
    beta-1,3-GalNAc-T2
    beta-1,3-N-acetylgalactosaminyltransferase II
    NP_001349333.1
    NP_001349334.1
    NP_848755.1
    XP_006516881.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362404.1 → NP_001349333.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      AK151677, CT009546
      Consensus CDS
      CCDS26246.1
      UniProtKB/Swiss-Prot
      Q5U4F9, Q8BG28, Q8BXL0
      Related
      ENSMUSP00000152397.2, ENSMUST00000221974.2
      Conserved Domains (1) summary
      cl21608
      Location:330 → 459
      Galactosyl_T; Galactosyltransferase

    2. NM_001362405.1 → NP_001349334.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      AK035259, AK151677
      Consensus CDS
      CCDS26246.1
      UniProtKB/Swiss-Prot
      Q5U4F9, Q8BG28, Q8BXL0
      Related
      ENSMUSP00000152755.2, ENSMUST00000221300.2
      Conserved Domains (1) summary
      cl21608
      Location:330 → 459
      Galactosyl_T; Galactosyltransferase

    3. NM_178640.3 → NP_848755.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

      See identical proteins and their annotated locations for NP_848755.1

      Status: VALIDATED

      Source sequence(s)
      CT009546
      Consensus CDS
      CCDS26246.1
      UniProtKB/Swiss-Prot
      Q5U4F9, Q8BG28, Q8BXL0
      Related
      ENSMUSP00000097336.4, ENSMUST00000099747.5
      Conserved Domains (1) summary
      cl21608
      Location:330 → 459
      Galactosyl_T; Galactosyltransferase

    RNA

    1. NR_155555.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK084275, AK134868, AK151677

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      14129059..14173688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516818.3 → XP_006516881.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 isoform X1

      Conserved Domains (1) summary
      cl21608
      Location:298 → 427
      Galactosyl_T; Galactosyltransferase

    RNA

    1. XR_873137.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG28.1 GenPept UniProtKB/Swiss-Prot:Q8BG28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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