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    Trpm3 transient receptor potential cation channel, subfamily M, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 226025, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trpm3provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 3provided by MGI
    Primary source
    MGI:MGI:2443101
    See related
    Ensembl:ENSMUSG00000052387 AllianceGenome:MGI:2443101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MLSN2; LTRPC3; 9330180E14; 6330504P12Rik; B930001P07Rik
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to act upstream of or within monoatomic cation transport. Predicted to be active in plasma membrane. Is expressed in cochlea; liver; nervous system; and retina. Used to study cataract and microphthalmia. Human ortholog(s) of this gene implicated in cataract. Orthologous to human TRPM3 (transient receptor potential cation channel subfamily M member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 5.1), genital fat pad adult (RPKM 2.9) and 7 other tissues See more
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    Genomic context

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    See Trpm3 in Genome Data Viewer
    Location:
    19 B; 19 16.05 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (22114789..22972774)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (22137797..22995410)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45740 Neighboring gene cell migration inducing hyaluronidase 2 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene lactate dehydrogenase B, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45741 Neighboring gene STARR-seq mESC enhancer starr_45742 Neighboring gene STARR-seq mESC enhancer starr_45744 Neighboring gene predicted gene, 22506 Neighboring gene ubiquitin-conjugating enzyme E2 D3-like Neighboring gene NSA2 ribosome biogenesis homolog, pseudogene 1 Neighboring gene predicted gene 27151 Neighboring gene predicted gene, 33649 Neighboring gene predicted gene, 54055 Neighboring gene STARR-seq mESC enhancer starr_45746 Neighboring gene microRNA 204 Neighboring gene RIKEN cDNA C330002G04 gene Neighboring gene STARR-seq mESC enhancer starr_45752 Neighboring gene STARR-seq mESC enhancer starr_45755 Neighboring gene STARR-seq mESC enhancer starr_45757 Neighboring gene STARR-seq mESC enhancer starr_45759 Neighboring gene RIKEN cDNA 2410080I02 gene Neighboring gene STARR-seq mESC enhancer starr_45760 Neighboring gene STARR-seq mESC enhancer starr_45763 Neighboring gene STARR-positive B cell enhancer ABC_E4273 Neighboring gene microRNA 1192 Neighboring gene Kruppel-like transcription factor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve Injury. Su S, et al. J Neurosci, 2021 Mar 17. PMID 33478988, Free PMC Article
    2. Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels. Dembla S, et al. Elife, 2017 Aug 15. PMID 28826482, Free PMC Article
    3. Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3. Duvoisin RM, et al. Invest Ophthalmol Vis Sci, 2017 May 1. PMID 28549093, Free PMC Article
    4. Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel. Held K, et al. J Physiol, 2018 Jun. PMID 29604058, Free PMC Article
    5. Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries. Alonso-Carbajo L, et al. J Mol Cell Cardiol, 2019 Apr. PMID 30853321

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon.
      Title: Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon.
    2. A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.
      Title: A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.
    3. TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain.
      Title: TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain.
    4. Vasoprotective effects of NOX4 are mediated via polymerase and transient receptor potential melastatin 2 cation channels in endothelial cells.
      Title: Vasoprotective effects of NOX4 are mediated via polymerase and transient receptor potential melastatin 2 cation channels in endothelial cells.
    5. Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
      Title: Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
    6. TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms.
      Title: TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms.
    7. TRPM3 Is Expressed in Afferent Bladder Neurons and Is Upregulated during Bladder Inflammation.
      Title: TRPM3 Is Expressed in Afferent Bladder Neurons and Is Upregulated during Bladder Inflammation.
    8. The Impact of Steroid Activation of TRPM3 on Spontaneous Activity in the Developing Retina.
      Title: The Impact of Steroid Activation of TRPM3 on Spontaneous Activity in the Developing Retina.
    9. Mutation of the TRPM3 cation channel underlies progressive cataract development and lens calcification associated with pro-fibrotic and immune cell responses.
      Title: Mutation of the TRPM3 cation channel underlies progressive cataract development and lens calcification associated with pro-fibrotic and immune cell responses.
    10. TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve Injury.
      Title: TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve Injury.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 3
    Names
    melastatin 2
    transient receptor potential melastatin 3 beta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035239.3 → NP_001030316.1  transient receptor potential cation channel subfamily M member 3 isoform a

      See identical proteins and their annotated locations for NP_001030316.1

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC132389, AC140411, AC164427
      Consensus CDS
      CCDS29702.1
      UniProtKB/TrEMBL
      Q5F4T0, Q69ZE8
      Related
      ENSMUSP00000157909.2, ENSMUST00000237820.2
      Conserved Domains (1) summary
      pfam16519
      Location:1233 → 1284
      TRPM_tetra; Tetramerization domain of TRPM

    2. NM_001035240.3 → NP_001030317.1  transient receptor potential cation channel subfamily M member 3 isoform b

      See identical proteins and their annotated locations for NP_001030317.1

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC132389, AC140411, AC164427
      Consensus CDS
      CCDS29703.1
      UniProtKB/TrEMBL
      Q5F4S9, Q69ZE8
      Related
      ENSMUSP00000084857.5, ENSMUST00000087576.12
      Conserved Domains (1) summary
      pfam16519
      Location:1233 → 1284
      TRPM_tetra; Tetramerization domain of TRPM

    3. NM_001035241.3 → NP_001030318.1  transient receptor potential cation channel subfamily M member 3 isoform c

      See identical proteins and their annotated locations for NP_001030318.1

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC132389, AC140411, AC164427
      Consensus CDS
      CCDS29704.1
      UniProtKB/TrEMBL
      Q5F4S8, Q69ZE8
      Related
      ENSMUSP00000074328.6, ENSMUST00000074770.13
      Conserved Domains (1) summary
      pfam16519
      Location:1223 → 1274
      TRPM_tetra; Tetramerization domain of TRPM

    4. NM_001035242.2 → NP_001030319.1  transient receptor potential cation channel subfamily M member 3 isoform d

      See identical proteins and their annotated locations for NP_001030319.1

      Status: VALIDATED

      Source sequence(s)
      AC132389, AC140411, AK173218, BB467120
      Consensus CDS
      CCDS89354.1
      UniProtKB/TrEMBL
      Q5F4S7, Q69ZE8
      Related
      ENSMUSP00000157607.2, ENSMUST00000237357.2
      Conserved Domains (1) summary
      pfam16519
      Location:1221 → 1272
      TRPM_tetra; Tetramerization domain of TRPM

    5. NM_001035243.3 → NP_001030320.1  transient receptor potential cation channel subfamily M member 3 isoform e

      See identical proteins and their annotated locations for NP_001030320.1

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC132389, AC140411, AC164427
      Consensus CDS
      CCDS89355.1
      UniProtKB/TrEMBL
      Q5F4S6, Q69ZE8
      Related
      ENSMUSP00000157673.2, ENSMUST00000236312.2
      Conserved Domains (1) summary
      pfam16519
      Location:1211 → 1262
      TRPM_tetra; Tetramerization domain of TRPM

    6. NM_001035244.2 → NP_001030321.1  transient receptor potential cation channel subfamily M member 3 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC164427, AK046908, AK051867, AK085182
      Consensus CDS
      CCDS37935.1
      UniProtKB/TrEMBL
      E9PUC8
      Related
      ENSMUSP00000097160.3, ENSMUST00000099564.10
      Conserved Domains (1) summary
      cl26777
      Location:713 → 869
      TRP_2; Transient receptor ion channel II

    7. NM_001035245.2 → NP_001030322.1  transient receptor potential cation channel subfamily M member 3 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC164427, AK082141, AK085182
      Consensus CDS
      CCDS50404.1
      UniProtKB/TrEMBL
      D3Z539
      Related
      ENSMUSP00000097162.4, ENSMUST00000099566.5
      Conserved Domains (1) summary
      pfam18139
      Location:1 → 230
      LSDAT_euk; SLOG in TRPM

    8. NM_001035246.2 → NP_001030323.1  transient receptor potential cation channel subfamily M member 3 isoform i

      See identical proteins and their annotated locations for NP_001030323.1

      Status: VALIDATED

      Source sequence(s)
      AC164427, AK044533, AK085182
      Related
      ENSMUST00000236009.2
      Conserved Domains (1) summary
      pfam18139
      Location:1 → 255
      LSDAT_euk; SLOG in TRPM

    9. NM_001362487.1 → NP_001349416.1  transient receptor potential cation channel subfamily M member 3 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ1, J9SUA7
      Conserved Domains (2) summary
      pfam16519
      Location:1256 → 1307
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:906 → 1224
      TRP_2; Transient receptor ion channel II

    10. NM_001362488.1 → NP_001349417.1  transient receptor potential cation channel subfamily M member 3 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ1, J9SQF8
      Conserved Domains (2) summary
      pfam16519
      Location:1246 → 1297
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:896 → 1214
      TRP_2; Transient receptor ion channel II

    11. NM_001362489.1 → NP_001349418.1  transient receptor potential cation channel subfamily M member 3 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ1, J9SQF3
      Conserved Domains (2) summary
      pfam16519
      Location:1244 → 1295
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:894 → 1212
      TRP_2; Transient receptor ion channel II

    12. NM_001362490.1 → NP_001349419.1  transient receptor potential cation channel subfamily M member 3 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      Consensus CDS
      CCDS89358.1
      UniProtKB/TrEMBL
      F4YJP9, J9S314
      Related
      ENSMUSP00000158045.2, ENSMUST00000235522.2
      Conserved Domains (2) summary
      pfam16519
      Location:1243 → 1294
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:881 → 1211
      TRP_2; Transient receptor ion channel II

    13. NM_001362491.1 → NP_001349420.1  transient receptor potential cation channel subfamily M member 3 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ0, F6M2J8
      Conserved Domains (2) summary
      pfam16519
      Location:1231 → 1282
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:881 → 1199
      TRP_2; Transient receptor ion channel II

    14. NM_001362496.1 → NP_001349425.1  transient receptor potential cation channel subfamily M member 3 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC132389, AC164427
      Consensus CDS
      CCDS89362.1
      UniProtKB/TrEMBL
      F7CJ77, Q3UQF1
      Related
      ENSMUSP00000097164.4, ENSMUST00000099569.10
      Conserved Domains (2) summary
      pfam16519
      Location:1091 → 1142
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:741 → 1059
      TRP_2; Transient receptor ion channel II

    15. NM_001362497.1 → NP_001349426.1  transient receptor potential cation channel subfamily M member 3 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      Conserved Domains (3) summary
      pfam16519
      Location:424 → 475
      TRPM_tetra; Tetramerisation domain of TRPM
      cl25602
      Location:394 → 503
      DUF3552; Domain of unknown function (DUF3552)
      cl26777
      Location:74 → 392
      TRP_2; Transient receptor ion channel II

    16. NM_001362498.1 → NP_001349427.1  transient receptor potential cation channel subfamily M member 3 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ2, J9T334
      Conserved Domains (2) summary
      pfam16519
      Location:1213 → 1264
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:863 → 1181
      TRP_2; Transient receptor ion channel II

    17. NM_001362499.1 → NP_001349428.1  transient receptor potential cation channel subfamily M member 3 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ1, J9T345
      Conserved Domains (2) summary
      pfam16519
      Location:1228 → 1279
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:878 → 1196
      TRP_2; Transient receptor ion channel II

    18. NM_001362500.1 → NP_001349429.1  transient receptor potential cation channel subfamily M member 3 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      Consensus CDS
      CCDS89359.1
      UniProtKB/TrEMBL
      F4YJQ0, J9T120
      Related
      ENSMUSP00000157511.2, ENSMUST00000236372.2
      Conserved Domains (2) summary
      pfam16519
      Location:1204 → 1255
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:748 → 1172
      TRP_2; Transient receptor ion channel II

    19. NM_001362501.1 → NP_001349430.1  transient receptor potential cation channel subfamily M member 3 isoform t

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ1, J9S305
      Conserved Domains (2) summary
      pfam16519
      Location:1234 → 1285
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:884 → 1202
      TRP_2; Transient receptor ion channel II

    20. NM_001362502.1 → NP_001349431.1  transient receptor potential cation channel subfamily M member 3 isoform u

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJP9, J9SQE7
      Conserved Domains (2) summary
      pfam16519
      Location:1231 → 1282
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:869 → 1199
      TRP_2; Transient receptor ion channel II

    21. NM_001362503.1 → NP_001349432.1  transient receptor potential cation channel subfamily M member 3 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJQ0, J9T143
      Conserved Domains (2) summary
      pfam16519
      Location:1221 → 1272
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:871 → 1189
      TRP_2; Transient receptor ion channel II

    22. NM_001362504.1 → NP_001349433.1  transient receptor potential cation channel subfamily M member 3 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      UniProtKB/TrEMBL
      F4YJP8, J9S2Y6
      Conserved Domains (2) summary
      pfam16519
      Location:1219 → 1270
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:869 → 1187
      TRP_2; Transient receptor ion channel II

    23. NM_001362505.1 → NP_001349434.1  transient receptor potential cation channel subfamily M member 3 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      Conserved Domains (3) summary
      pfam16519
      Location:424 → 475
      TRPM_tetra; Tetramerisation domain of TRPM
      cl25602
      Location:394 → 503
      DUF3552; Domain of unknown function (DUF3552)
      cl26777
      Location:74 → 392
      TRP_2; Transient receptor ion channel II

    24. NM_001362506.1 → NP_001349435.1  transient receptor potential cation channel subfamily M member 3 isoform y

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      Consensus CDS
      CCDS89357.1
      UniProtKB/TrEMBL
      F4YJQ2, J9S2Z5
      Related
      ENSMUSP00000157646.2, ENSMUST00000238066.2
      Conserved Domains (2) summary
      pfam16519
      Location:1201 → 1252
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:851 → 1169
      TRP_2; Transient receptor ion channel II

    25. NM_001362507.1 → NP_001349436.1  transient receptor potential cation channel subfamily M member 3 isoform z

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      Consensus CDS
      CCDS89356.1
      UniProtKB/TrEMBL
      F4YJQ2, J9T153
      Related
      ENSMUSP00000158494.2, ENSMUST00000235780.2
      Conserved Domains (2) summary
      pfam16519
      Location:1203 → 1254
      TRPM_tetra; Tetramerisation domain of TRPM
      cl26777
      Location:853 → 1171
      TRP_2; Transient receptor ion channel II

    26. NM_001362508.1 → NP_001349437.1  transient receptor potential cation channel subfamily M member 3 isoform aa

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC132389
      Conserved Domains (2) summary
      TIGR00870
      Location:18 → 265
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:293 → 347
      TRPM_tetra; Tetramerisation domain of TRPM

    27. NM_001362511.1 → NP_001349440.1  transient receptor potential cation channel subfamily M member 3 isoform bb

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC164427, AK052064
      Consensus CDS
      CCDS89361.1
      UniProtKB/TrEMBL
      A0A494BA79
      Related
      ENSMUSP00000157917.2, ENSMUST00000235712.2

    28. NM_001362512.1 → NP_001349441.1  transient receptor potential cation channel subfamily M member 3 isoform cc

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC164427, AK161909
      Conserved Domains (1) summary
      pfam18139
      Location:1 → 255
      LSDAT_euk; SLOG in TRPM

    29. NM_001362513.1 → NP_001349442.1  transient receptor potential cation channel subfamily M member 3 issform dd

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC164427, AK051934
      Conserved Domains (1) summary
      pfam18139
      Location:1 → 258
      LSDAT_euk; SLOG in TRPM

    30. NM_177341.5 → NP_796315.2  transient receptor potential cation channel subfamily M member 3 isoform f

      See identical proteins and their annotated locations for NP_796315.2

      Status: VALIDATED

      Source sequence(s)
      AC123066, AC124513, AC132389, AC164427
      Consensus CDS
      CCDS29705.1
      UniProtKB/TrEMBL
      B2RUS0
      Related
      ENSMUSP00000042184.7, ENSMUST00000037901.14
      Conserved Domains (3) summary
      TIGR00870
      Location:881 → 1199
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1227 → 1282
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:153 → 418
      LSDAT_euk; SLOG in TRPM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      22114789..22972774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526954.5 → XP_006527017.1  transient receptor potential cation channel subfamily M member 3 isoform X1

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:908 → 1238
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1266 → 1321
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    2. XM_006526979.5 → XP_006527042.1  transient receptor potential cation channel subfamily M member 3 isoform X14

      Conserved Domains (3) summary
      TIGR00870
      Location:908 → 1238
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1266 → 1321
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    3. XM_006526957.5 → XP_006527020.1  transient receptor potential cation channel subfamily M member 3 isoform X4

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:908 → 1226
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1254 → 1309
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    4. XM_011247233.4 → XP_011245535.1  transient receptor potential cation channel subfamily M member 3 isoform X15

      Conserved Domains (3) summary
      TIGR00870
      Location:908 → 1226
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1254 → 1309
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    5. XM_006526956.5 → XP_006527019.1  transient receptor potential cation channel subfamily M member 3 isoform X3

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:898 → 1228
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1256 → 1311
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    6. XM_017318155.3 → XP_017173644.1  transient receptor potential cation channel subfamily M member 3 isoform X6

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:898 → 1216
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1244 → 1299
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    7. XM_006526958.5 → XP_006527021.1  transient receptor potential cation channel subfamily M member 3 isoform X5

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:896 → 1226
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1254 → 1309
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    8. XM_006526961.5 → XP_006527024.1  transient receptor potential cation channel subfamily M member 3 isoform X7

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:896 → 1214
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1242 → 1297
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    9. XM_006526966.5 → XP_006527029.1  transient receptor potential cation channel subfamily M member 3 isoform X9

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:886 → 1204
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1232 → 1287
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 445
      LSDAT_euk; SLOG in TRPM

    10. XM_006526963.5 → XP_006527026.1  transient receptor potential cation channel subfamily M member 3 isoform X8

      UniProtKB/TrEMBL
      Q69ZE8
      Conserved Domains (3) summary
      TIGR00870
      Location:883 → 1213
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1241 → 1296
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:155 → 420
      LSDAT_euk; SLOG in TRPM

    11. XM_030250889.2 → XP_030106749.1  transient receptor potential cation channel subfamily M member 3 isoform X18

      UniProtKB/TrEMBL
      Q8BJE6
      Conserved Domains (1) summary
      pfam18139
      Location:155 → 410
      LSDAT_euk; SLOG in TRPM

    12. XM_017318158.2 → XP_017173647.1  transient receptor potential cation channel subfamily M member 3 isoform X20

      UniProtKB/TrEMBL
      Q8BJE6
      Conserved Domains (1) summary
      pfam18139
      Location:155 → 385
      LSDAT_euk; SLOG in TRPM

    13. XM_030250888.2 → XP_030106748.1  transient receptor potential cation channel subfamily M member 3 isoform X17

      UniProtKB/TrEMBL
      Q8BKI1
      Conserved Domains (1) summary
      pfam18139
      Location:155 → 413
      LSDAT_euk; SLOG in TRPM

    14. XM_036161556.1 → XP_036017449.1  transient receptor potential cation channel subfamily M member 3 isoform X19

      UniProtKB/TrEMBL
      Q8BKI1
      Conserved Domains (1) summary
      pfam18139
      Location:155 → 388
      LSDAT_euk; SLOG in TRPM

    15. XM_036161554.1 → XP_036017447.1  transient receptor potential cation channel subfamily M member 3 isoform X11

      UniProtKB/TrEMBL
      F4YJP9
      Conserved Domains (3) summary
      TIGR00870
      Location:871 → 1201
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1229 → 1283
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:153 → 418
      LSDAT_euk; SLOG in TRPM

    16. XM_006526974.5 → XP_006527037.1  transient receptor potential cation channel subfamily M member 3 isoform X10

      See identical proteins and their annotated locations for XP_006527037.1

      UniProtKB/TrEMBL
      F4YJP8, J9SVL3
      Related
      ENSMUSP00000157503.2, ENSMUST00000236804.2
      Conserved Domains (3) summary
      TIGR00870
      Location:859 → 1177
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1205 → 1260
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:153 → 418
      LSDAT_euk; SLOG in TRPM

    17. XM_006526955.5 → XP_006527018.1  transient receptor potential cation channel subfamily M member 3 isoform X2

      UniProtKB/TrEMBL
      F4YJQ1
      Conserved Domains (3) summary
      TIGR00870
      Location:906 → 1236
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1264 → 1319
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:153 → 443
      LSDAT_euk; SLOG in TRPM

    18. XM_036161557.1 → XP_036017450.1  transient receptor potential cation channel subfamily M member 3 isoform X21

      UniProtKB/TrEMBL
      Q8BJE6
      Conserved Domains (1) summary
      pfam18139
      Location:153 → 383
      LSDAT_euk; SLOG in TRPM

    19. XM_006526978.4 → XP_006527041.1  transient receptor potential cation channel subfamily M member 3 isoform X13

      UniProtKB/TrEMBL
      Q3UQF1
      Conserved Domains (3) summary
      TIGR00870
      Location:728 → 1058
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1086 → 1141
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:1 → 265
      LSDAT_euk; SLOG in TRPM

    20. XM_036161558.1 → XP_036017451.1  transient receptor potential cation channel subfamily M member 3 isoform X22

      Conserved Domains (1) summary
      pfam18139
      Location:1 → 233
      LSDAT_euk; SLOG in TRPM

    21. XM_006526975.4 → XP_006527038.1  transient receptor potential cation channel subfamily M member 3 isoform X12

      See identical proteins and their annotated locations for XP_006527038.1

      UniProtKB/TrEMBL
      Q3UQF1
      Conserved Domains (3) summary
      TIGR00870
      Location:753 → 1083
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1111 → 1166
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:1 → 290
      LSDAT_euk; SLOG in TRPM

    22. XM_006526976.5 → XP_006527039.1  transient receptor potential cation channel subfamily M member 3 isoform X12

      See identical proteins and their annotated locations for XP_006527039.1

      UniProtKB/TrEMBL
      Q3UQF1
      Conserved Domains (3) summary
      TIGR00870
      Location:753 → 1083
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:1111 → 1166
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:1 → 290
      LSDAT_euk; SLOG in TRPM

    23. XM_036161555.1 → XP_036017448.1  transient receptor potential cation channel subfamily M member 3 isoform X16

      Conserved Domains (2) summary
      TIGR00870
      Location:18 → 265
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:293 → 347
      TRPM_tetra; Tetramerisation domain of TRPM

    24. XM_030250887.1 → XP_030106747.1  transient receptor potential cation channel subfamily M member 3 isoform X16

      Conserved Domains (2) summary
      TIGR00870
      Location:18 → 265
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:293 → 347
      TRPM_tetra; Tetramerisation domain of TRPM

    RNA

    1. XR_003952780.2 RNA Sequence

    2. XR_003952781.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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