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    Insyn2a inhibitory synaptic factor 2A [ Mus musculus (house mouse) ]

    Gene ID: 627214, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Insyn2aprovided by MGI
    Official Full Name
    inhibitory synaptic factor 2Aprovided by MGI
    Primary source
    MGI:MGI:3605068
    See related
    Ensembl:ENSMUSG00000073805 AllianceGenome:MGI:3605068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    InSyn2; Fam196a; B830028B13Rik
    Summary
    Involved in inhibitory postsynaptic potential. Located in postsynaptic density. Is active in GABA-ergic synapse and postsynaptic specialization. Orthologous to human INSYN2A (inhibitory synaptic factor 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 1.9), CNS E18 (RPKM 1.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Insyn2a in Genome Data Viewer
    Location:
    7 F3; 7 80.86 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (134483637..134540159, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (134881908..134938430, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 7, ERATO Doi 443, expressed Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene Neighboring gene dedicator of cytokinesis 1 Neighboring gene STARR-seq mESC enhancer starr_20355 Neighboring gene STARR-seq mESC enhancer starr_20356 Neighboring gene VISTA enhancer mm1401 Neighboring gene RIKEN cDNA 1700120G07 gene Neighboring gene STARR-seq mESC enhancer starr_20359 Neighboring gene predicted gene, 24581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of an elaborate complex mediating postsynaptic inhibition. Uezu A, et al. Science, 2016 Sep 9. PMID 27609886, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Clone Names

    • MGC189982, MGC189985

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission, postsynaptic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission, postsynaptic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inhibitory postsynaptic potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inhibitory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitory synaptic factor 2A
    Names
    family with sequence similarity 196, member A
    protein FAM196A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143802.1 → NP_001137274.1  inhibitory synaptic factor 2A

      Status: VALIDATED

      Source sequence(s)
      AC100208, AC127574
      Consensus CDS
      CCDS52419.1
      UniProtKB/Swiss-Prot
      B2RY32, Q3USH1
      UniProtKB/TrEMBL
      E9PZW7
      Related
      ENSMUSP00000129222.2, ENSMUST00000171394.3
      Conserved Domains (1) summary
      pfam15265
      Location:1 → 470
      FAM196; FAM196 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      134483637..134540159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508103.5 → XP_006508166.1  inhibitory synaptic factor 2A isoform X2

      UniProtKB/Swiss-Prot
      B2RY32, Q3USH1
      Conserved Domains (1) summary
      pfam15265
      Location:19 → 464
      FAM196; FAM196 family

    2. XM_017322443.3 → XP_017177932.1  inhibitory synaptic factor 2A isoform X1

      UniProtKB/Swiss-Prot
      B2RY32, Q3USH1
      Conserved Domains (1) summary
      pfam15265
      Location:19 → 488
      FAM196; FAM196 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3USH1.1 GenPept UniProtKB/Swiss-Prot:Q3USH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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