Gpr179 G protein-coupled receptor 179 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr179provided by MGI
Official Full Name: G protein-coupled receptor 179provided by MGI
Primary source: MGI:MGI:2443409
See related: Ensembl:ENSMUSG00000070337 AllianceGenome:MGI:2443409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr158l1; 5330439C02Rik
Summary: Predicted to enable G protein-coupled receptor activity. Involved in visual perception. Acts upstream of or within protein localization to plasma membrane and response to light stimulus. Located in dendrite terminus. Is active in cell tip; dendrite; and postsynaptic membrane. Used to study congenital stationary night blindness 1E. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1E. Orthologous to human GPR179 (G protein-coupled receptor 179). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 1.5), adrenal adult (RPKM 0.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 60.95 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97222935..97243182, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97332109..97352356, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia.
Title: Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia.
Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179.
Title: Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179.
Authors identify that major components of the extracellular matrix proteins present in the synaptic cleft-members of the heparan sulfate proteoglycan (HSPG) family-associate with the GPR158/179 group of orphan receptors.
Title: Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.
A no b-wave (nob) electroretinography phenotype arose spontaneously in a colony of C3H mice and was named nob5. A mutation was identified in the Gpr179 gene in homozygous nob5 mice.
Title: Survey of the nob5 mutation in C3H substrains.
This study showed that GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells in mice.
Title: GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells.
For most of the mutations identified so far, loss of the GPR179 protein function seems to be the underlying pathogenic mechanism leading to this form of cCSNB.
Title: Further insights into GPR179: expression, localization, and associated pathogenic mechanisms leading to complete congenital stationary night blindness.
GPR179 forms physical complexes with the main components of the metabotropic cascade, recruiting mGluR6, TRPM1, and the Regulators of G-Protein Signaling Proteins.
Title: Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.
The loss of GPR179 in a mouse model of night blindness prevented targeting of RGS to the postsynaptic compartment of bipolar neurons in the retina, illuminating the role of GPR179 in night vision.
Title: GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Spontaneous (1) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite terminus	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: G-protein coupled receptor 179

Names: GPR158-like 1 receptor; probable G-protein coupled receptor 179

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081220.2 → NP_001074689.1 G-protein coupled receptor 179 precursor

See identical proteins and their annotated locations for NP_001074689.1

Status: VALIDATED

Source sequence(s)

AL596088

Consensus CDS

CCDS36292.1

UniProtKB/Swiss-Prot

E9PY61

Related

ENSMUSP00000091474.5, ENSMUST00000093942.5

Conserved Domains (2) summary

cd00054
Location:278 → 327

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00003
Location:392 → 632

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

97222935..97243182 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533025.3 → XP_006533088.1 G-protein coupled receptor 179 isoform X1

Conserved Domains (1) summary

cd15293
Location:11 → 234

7tmC_GPR158-like; orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175453.2: Suppressed sequence

Description

NM_175453.2: This RefSeq was removed because there is insufficient support for the transcript and protein.