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    Slc35c2 solute carrier family 35, member C2 [ Mus musculus (house mouse) ]

    Gene ID: 228875, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc35c2provided by MGI
    Official Full Name
    solute carrier family 35, member C2provided by MGI
    Primary source
    MGI:MGI:2385166
    See related
    Ensembl:ENSMUSG00000017664 AllianceGenome:MGI:2385166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-15; Ovcov1; D2Wsu58e
    Summary
    Predicted to enable antiporter activity. Acts upstream of or within negative regulation of gene expression; positive regulation of Notch signaling pathway; and protein O-linked fucosylation. Predicted to be located in nucleoplasm. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and gonad. Orthologous to human SLC35C2 (solute carrier family 35 member C2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 63.1), small intestine adult (RPKM 33.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35c2 in Genome Data Viewer
    Location:
    2 H3; 2 85.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165118442..165129808, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165276522..165287888, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cadherin 22 Neighboring gene predicted gene, 36748 Neighboring gene predicted gene, 25569 Neighboring gene engulfment and cell motility 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene zinc finger protein 663 Neighboring gene predicted gene, 29831

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification, molecular characterization, and tissue expression of OVCOV1. Leach RE, et al. Mamm Genome, 2002 Nov. PMID 12461647
    2. In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2. Lu L, et al. J Biol Chem, 2023 Dec. PMID 38270391, Free PMC Article
    3. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Jabbour L, et al. Genomics, 2003 Mar. PMID 12659813
    4. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. Lu L, et al. J Biol Chem, 2010 Nov 12. PMID 20837470, Free PMC Article
    5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Slc35c2 enhances fucosylation of Notch1.
      Title: Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18664

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein O-linked fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein O-linked fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 35 member C2
    Names
    ovarian cancer overexpressed gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252573.1 → NP_001239502.1  solute carrier family 35 member C2 isoform 1

      See identical proteins and their annotated locations for NP_001239502.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
      Source sequence(s)
      AL591430
      Consensus CDS
      CCDS17074.1
      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Related
      ENSMUSP00000104921.2, ENSMUST00000109298.8
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    2. NM_001252574.1 → NP_001239503.1  solute carrier family 35 member C2 isoform 1

      See identical proteins and their annotated locations for NP_001239503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
      Source sequence(s)
      AL591430
      Consensus CDS
      CCDS17074.1
      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Related
      ENSMUSP00000104922.2, ENSMUST00000109299.8
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    3. NM_001252575.1 → NP_001239504.1  solute carrier family 35 member C2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK053180, BB772752, BB849961
      Conserved Domains (1) summary
      pfam03151
      Location:3 → 199
      TPT; Triose-phosphate Transporter family

    4. NM_001363015.1 → NP_001349944.1  solute carrier family 35 member C2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, 3, and 6, encodes isoform 1.
      Source sequence(s)
      AL591430
      Consensus CDS
      CCDS17074.1
      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Related
      ENSMUSP00000017808.8, ENSMUST00000017808.14
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    5. NM_001363016.1 → NP_001349945.1  solute carrier family 35 member C2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, 3, and 5, encodes isoform 1.
      Source sequence(s)
      AL591430
      Consensus CDS
      CCDS17074.1
      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    6. NM_144893.2 → NP_659142.1  solute carrier family 35 member C2 isoform 1

      See identical proteins and their annotated locations for NP_659142.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same isoform (1).
      Source sequence(s)
      AK160899, BB772752, BB849961, BE952356
      Consensus CDS
      CCDS17074.1
      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Related
      ENSMUSP00000104923.3, ENSMUST00000109300.9
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165118442..165129808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499371.4 → XP_006499434.1  solute carrier family 35 member C2 isoform X1

      See identical proteins and their annotated locations for XP_006499434.1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    2. XM_030250667.2 → XP_030106527.1  solute carrier family 35 member C2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    3. XM_030250672.2 → XP_030106532.1  solute carrier family 35 member C2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    4. XM_036161632.1 → XP_036017525.1  solute carrier family 35 member C2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    5. XM_006499372.5 → XP_006499435.1  solute carrier family 35 member C2 isoform X1

      See identical proteins and their annotated locations for XP_006499435.1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    6. XM_006499375.5 → XP_006499438.1  solute carrier family 35 member C2 isoform X1

      See identical proteins and their annotated locations for XP_006499438.1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    7. XM_030250671.2 → XP_030106531.1  solute carrier family 35 member C2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    8. XM_030250673.2 → XP_030106533.1  solute carrier family 35 member C2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCX2
      UniProtKB/TrEMBL
      Q3U226, Q5GMH2
      Conserved Domains (1) summary
      cd21092
      Location:80 → 327
      TPT_S35C2; solute carrier family 35 member C2, member of the triose-phosphate transporter family

    RNA

    1. XR_003952694.2 RNA Sequence

    2. XR_001782366.1 RNA Sequence

      Related
      ENSMUST00000132270.8

    3. XR_004940155.1 RNA Sequence

    4. XR_004940156.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCX2.1 GenPept UniProtKB/Swiss-Prot:Q8VCX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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