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    ERG28 Erg28p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERG28
    Official Full Name
    Erg28p
    Primary source
    SGD:S000000846
    Locus tag
    YER044C
    See related
    AllianceGenome:SGD:S000000846; FungiDB:YER044C; VEuPathDB:YER044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BUD18
    Summary
    Enables protein-macromolecule adaptor activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane. Orthologous to human ERG28 (ergosterol biosynthesis 28 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERG28 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (237570..238016, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene peptide-methionine-S-sulfoxide reductase Neighboring gene adenosylhomocysteinase Neighboring gene Mei4p Neighboring gene Aca1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular mechanism of a cis-regulatory adaptation in yeast. Chang J, et al. PLoS Genet, 2013. PMID 24068973, Free PMC Article
    2. Identification of a consensus motif in Erg28p required for C-4 demethylation in yeast ergosterol biosynthesis based on mutation analysis. Ke X, et al. FEMS Microbiol Lett, 2018 Mar 1. PMID 29319811
    3. The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). Mo C, et al. Biochim Biophys Acta, 2004 Nov 8. PMID 15522820
    4. The genomic structure of c14orf1 is conserved across eukarya. Ottolenghi C, et al. Mamm Genome, 2000 Sep. PMID 10967139
    5. Actin cytoskeletal inhibitor 19,20-epoxycytochalasin Q sensitizes yeast cells lacking ERG6 through actin-targeting and secondarily through disruption of lipid homeostasis. Watchaputi K, et al. Sci Rep, 2021 Apr 8. PMID 33833332, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Erg28p
    NP_010962.1
    • Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      237570..238016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178935.1 → NP_010962.1  TPA: Erg28p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010962.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU4, P40030
      UniProtKB/TrEMBL
      A6ZQZ3, B3LS57, C7GSJ1, C8Z747, G2WCS7, N1P6W7
      Conserved Domains (1) summary
      pfam03694
      Location:21 → 130
      Erg28; Erg28 like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40030.1

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