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    Cpsf2 cleavage and polyadenylation specific factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 51786, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cpsf2provided by MGI
    Official Full Name
    cleavage and polyadenylation specific factor 2provided by MGI
    Primary source
    MGI:MGI:1861601
    See related
    Ensembl:ENSMUSG00000041781 AllianceGenome:MGI:1861601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpsf; MCPSF; 100kDa; mKIAA1367; 2610024B04Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Part of mRNA cleavage and polyadenylation specificity factor complex. Is active in glutamatergic synapse and postsynapse. Is expressed in 2-cell stage embryo. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.5), liver E14 (RPKM 8.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cpsf2 in Genome Data Viewer
    Location:
    12 E; 12 51.34 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101940345..101972252)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101975759..102005993)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene predicted gene, 20036 Neighboring gene STARR-positive B cell enhancer ABC_E1452 Neighboring gene ataxin 3 Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene Ras and Rab interactor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Rift Valley Fever virus protein NSm and putative cellular protein interactions. Engdahl C, et al. Virol J, 2012 Jul 28. PMID 22838834, Free PMC Article
    2. N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. Huang YS, et al. EMBO J, 2002 May 1. PMID 11980711, Free PMC Article
    3. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
    4. Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. Collart C, et al. Genes Cells, 2005 Sep. PMID 16115198
    5. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Udagawa T, et al. Mol Cell, 2012 Jul 27. PMID 22727665, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cpsf2,Ppil2, and SNAP-25 are the most promising targets for the NSm protein of the virus during an infection.
      Title: The Rift Valley Fever virus protein NSm and putative cellular protein interactions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor subunit 2
    Names
    CPSF 100 kDa subunit
    cleavage and polyadenylation specific factor 2, 100kD subunit
    cleavage and polyadenylation specificity factor 100 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016856.3 → NP_058552.1  cleavage and polyadenylation specificity factor subunit 2

      See identical proteins and their annotated locations for NP_058552.1

      Status: VALIDATED

      Source sequence(s)
      AF012822, AK078904, AK084961, AK147746, BE951303
      Consensus CDS
      CCDS26116.1
      UniProtKB/Swiss-Prot
      O35218
      Related
      ENSMUSP00000047797.9, ENSMUST00000047357.10
      Conserved Domains (4) summary
      smart01027
      Location:243 → 368
      Beta-Casp; Beta-Casp domain
      cd16293
      Location:7 → 204
      CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
      pfam13299
      Location:608 → 779
      CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
      pfam07521
      Location:528 → 591
      RMMBL; Zn-dependent metallo-hydrolase RNA specificity domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      101940345..101972252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516071.5 → XP_006516134.1  cleavage and polyadenylation specificity factor subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006516134.1

      UniProtKB/Swiss-Prot
      O35218
      Conserved Domains (4) summary
      smart01027
      Location:243 → 368
      Beta-Casp; Beta-Casp domain
      cd16293
      Location:7 → 204
      CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
      pfam13299
      Location:608 → 779
      CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
      pfam07521
      Location:528 → 591
      RMMBL; Zn-dependent metallo-hydrolase RNA specificity domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35218.1 GenPept UniProtKB/Swiss-Prot:O35218

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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