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    TAAR2 trace amine associated receptor 2 [ Homo sapiens (human) ]

    Gene ID: 9287, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAAR2provided by HGNC
    Official Full Name
    trace amine associated receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:4514
    See related
    Ensembl:ENSG00000146378 MIM:604849; AllianceGenome:HGNC:4514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR58; taR-2
    Summary
    Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See TAAR2 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132617150..132624275, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133812108..133819243, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132938289..132945414, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 5 Neighboring gene trace amine associated receptor 4, pseudogene Neighboring gene trace amine associated receptor 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17552 Neighboring gene trace amine associated receptor 1 Neighboring gene HLF pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2. Babusyte A, et al. J Leukoc Biol, 2013 Mar. PMID 23315425
    2. Cloning and characterization of additional members of the G protein-coupled receptor family. Lee DK, et al. Biochim Biophys Acta, 2000 Feb 29. PMID 10684976
    3. A second class of chemosensory receptors in the olfactory epithelium. Liberles SD, et al. Nature, 2006 Aug 10. PMID 16878137
    4. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Lindemann L, et al. Genomics, 2005 Mar. PMID 15718104
    5. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Luttrell LM. Mol Biotechnol, 2008 Jul. PMID 18240029

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables trace-amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trace amine-associated receptor 2
    Names
    G protein-coupled receptor 58

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033080.1 → NP_001028252.1  trace amine-associated receptor 2 isoform 1

      See identical proteins and their annotated locations for NP_001028252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY703480
      Consensus CDS
      CCDS34541.1
      UniProtKB/Swiss-Prot
      Q5QD02, Q6NWS1, Q6NWS2, Q6NWS3, Q9P1P5
      Related
      ENSP00000356908.1, ENST00000367931.1
      Conserved Domains (2) summary
      pfam00001
      Location:60 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:53 → 180
      7tm_4; Olfactory receptor

    2. NM_014626.3 → NP_055441.2  trace amine-associated receptor 2 isoform 2

      See identical proteins and their annotated locations for NP_055441.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AY702304, DN693314
      Consensus CDS
      CCDS5157.1
      UniProtKB/Swiss-Prot
      Q9P1P5
      Related
      ENSP00000275191.2, ENST00000275191.2
      Conserved Domains (2) summary
      pfam00001
      Location:15 → 270
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:8 → 135
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      132617150..132624275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133812108..133819243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P1P5.2 GenPept UniProtKB/Swiss-Prot:Q9P1P5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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