U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CPAMD8 C3 and PZP like alpha-2-macroglobulin domain containing 8 [ Homo sapiens (human) ]

    Gene ID: 27151, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CPAMD8provided by HGNC
    Official Full Name
    C3 and PZP like alpha-2-macroglobulin domain containing 8provided by HGNC
    Primary source
    HGNC:HGNC:23228
    See related
    Ensembl:ENSG00000160111 MIM:608841; AllianceGenome:HGNC:23228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VIP; ASGD8; K-CAP
    Summary
    This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017]
    Expression
    Biased expression in lung (RPKM 10.3), prostate (RPKM 7.9) and 12 other tissues See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CPAMD8 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (16892951..17026810, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17027788..17161726, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17003762..17137620, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16939935-16940436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14248 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16947461-16947962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16957115-16957616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16957617-16958116 Neighboring gene SIN3 transcription regulator family member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16996894-16997394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17000485-17001084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10318 Neighboring gene RNA, 7SL, cytoplasmic 835, pseudogene Neighboring gene F2R like thrombin or trypsin receptor 3 Neighboring gene RNA, 7SL, cytoplasmic 823, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17062521-17063084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17071591-17072150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17072151-17072708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17137792-17138700 Neighboring gene Sharpr-MPRA regulatory region 9643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10319 Neighboring gene Sharpr-MPRA regulatory region 7940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17190569-17191106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17192643-17193192 Neighboring gene HAUS augmin like complex subunit 8 Neighboring gene myosin IXB Neighboring gene small nucleolar RNA, H/ACA box 118

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biallelic variants in CPAMD8 are associated with primary open-angle glaucoma and primary angle-closure glaucoma. Li X, et al. Br J Ophthalmol, 2022 Dec. PMID 34154991
    2. Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma. Siggs OM, et al. Ophthalmology, 2020 Jun. PMID 32085876
    3. Identification and characterization of CPAMD8, a novel member of the complement 3/alpha2-macroglobulin family with a C-terminal Kazal domain. Li ZF, et al. Genomics, 2004 Jun. PMID 15177561
    4. CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix. Bonet-Fernández JM, et al. Hum Genet, 2020 Oct. PMID 32274568
    5. Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release. Felley CP, et al. Am J Physiol, 1992 Dec. PMID 1335692

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic variants in CPAMD8 are associated with primary open-angle glaucoma and primary angle-closure glaucoma.
      Title: Biallelic variants in CPAMD8 are associated with primary open-angle glaucoma and primary angle-closure glaucoma.
    2. Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma.
      Title: Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma.
    3. CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix.
      Title: CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix.
    4. study delineates a unique form of recessive anterior segment dysgeneses (ASD) and defines a role for CPAMD8, a protein of unknown function, in anterior segment development, implying another pathway for the pathogenicity of ASD
      Title: Mutations in CPAMD8 Cause a Unique Form of Autosomal-Recessive Anterior Segment Dysgenesis.
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    7. a novel member of the complement 3/alpha(2)-macroglobulin (C3/alpha(2)M) family named CPAMD8 has been identified and characterized.
      Title: Identification and characterization of CPAMD8, a novel member of the complement 3/alpha2-macroglobulin family with a C-terminal Kazal domain.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Anterior segment dysgenesis 8
    MedGen: C4310622 OMIM: 617319 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ42058, FLJ90618, KIAA1283

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
    Names
    alpha-2 macroglobulin family protein VIP

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054892.1 RefSeqGene

      Range
      5009..138868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015692.5 → NP_056507.3  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AC008737, AC020908, AI670110, AY101765, BC067854, BF726092, BP302427
      Consensus CDS
      CCDS42519.2
      UniProtKB/Swiss-Prot
      Q8IZJ3, Q8NC09, Q9ULD7
      UniProtKB/TrEMBL
      A0A494C0S9
      Related
      ENSP00000402505.3, ENST00000443236.7
      Conserved Domains (8) summary
      smart00280
      Location:1712 → 1744
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1141 → 1429
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:750 → 841
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1569 → 1659
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:455 → 626
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:991 → 1086
      Methyltransf_FA; Farnesoic acid 0-methyl transferase
      cl26464
      Location:1640 → 1844
      Atrophin-1; Atrophin-1 family

    RNA

    1. NR_147452.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a downstream promoter compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
      Source sequence(s)
      AC008737, AY101765, DA368557
      Related
      ENST00000594249.6

    2. NR_165644.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AC020908
      Related
      ENST00000291440.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      16892951..17026810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527917.2 → XP_011526219.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A494C0S9
      Conserved Domains (8) summary
      smart00280
      Location:1747 → 1779
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1176 → 1464
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:785 → 876
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:164 → 256
      A2M_N; MG2 domain
      pfam07677
      Location:1604 → 1694
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1217 → 1466
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:492 → 660
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1020 → 1121
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    2. XM_047438612.1 → XP_047294568.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A494C0S9

    3. XM_011527922.2 → XP_011526224.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      See identical proteins and their annotated locations for XP_011526224.1

      UniProtKB/TrEMBL
      A0A494C0S9
      Conserved Domains (8) summary
      smart00280
      Location:1759 → 1791
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1188 → 1476
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:797 → 888
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:176 → 268
      A2M_N; MG2 domain
      pfam07677
      Location:1616 → 1706
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1229 → 1478
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:504 → 672
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1032 → 1133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    4. XM_011527921.4 → XP_011526223.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      See identical proteins and their annotated locations for XP_011526223.1

      UniProtKB/TrEMBL
      A0A494C0S9
      Conserved Domains (8) summary
      smart00280
      Location:1759 → 1791
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1188 → 1476
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:797 → 888
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:176 → 268
      A2M_N; MG2 domain
      pfam07677
      Location:1616 → 1706
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1229 → 1478
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:504 → 672
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1032 → 1133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    5. XM_011527924.3 → XP_011526226.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      See identical proteins and their annotated locations for XP_011526226.1

      UniProtKB/TrEMBL
      A0A494C0S9
      Conserved Domains (8) summary
      smart00280
      Location:1759 → 1791
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1188 → 1476
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:797 → 888
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:176 → 268
      A2M_N; MG2 domain
      pfam07677
      Location:1616 → 1706
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1229 → 1478
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:504 → 672
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1032 → 1133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    6. XM_011527918.2 → XP_011526220.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A494C0S9
      Conserved Domains (8) summary
      smart00280
      Location:1759 → 1791
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1188 → 1476
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:797 → 888
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:176 → 268
      A2M_N; MG2 domain
      pfam07677
      Location:1616 → 1706
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1229 → 1478
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:504 → 672
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1032 → 1133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    7. XM_011527919.2 → XP_011526221.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A494C0S9
      Related
      ENSP00000498697.2, ENST00000651564.2
      Conserved Domains (8) summary
      smart00280
      Location:1759 → 1791
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1188 → 1476
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:797 → 888
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:176 → 268
      A2M_N; MG2 domain
      pfam07677
      Location:1616 → 1706
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1229 → 1478
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:504 → 672
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1032 → 1133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    8. XM_011527920.3 → XP_011526222.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A494C0S9
      Conserved Domains (8) summary
      smart00280
      Location:1759 → 1791
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1188 → 1476
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:797 → 888
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:176 → 268
      A2M_N; MG2 domain
      pfam07677
      Location:1616 → 1706
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1229 → 1478
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:504 → 672
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1032 → 1133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    9. XM_047438613.1 → XP_047294569.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A494C0S9

    10. XM_047438614.1 → XP_047294570.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A494C0S9

    11. XM_011527925.1 → XP_011526227.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X9

      Conserved Domains (6) summary
      smart00280
      Location:1016 → 1048
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:445 → 733
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:54 → 145
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:873 → 963
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:486 → 735
      A2M_comp; A-macroglobulin complement component
      pfam12248
      Location:289 → 390
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    12. XM_011527923.2 → XP_011526225.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      See identical proteins and their annotated locations for XP_011526225.1

      UniProtKB/TrEMBL
      A0A494C0S9
      Conserved Domains (8) summary
      smart00280
      Location:1759 → 1791
      KAZAL; Kazal type serine protease inhibitors
      cd02897
      Location:1188 → 1476
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:797 → 888
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:176 → 268
      A2M_N; MG2 domain
      pfam07677
      Location:1616 → 1706
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1229 → 1478
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:504 → 672
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam12248
      Location:1032 → 1133
      Methyltransf_FA; Farnesoic acid 0-methyl transferase

    13. XM_017026594.2 → XP_016882083.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A494C0S9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      17027788..17161726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320552.1 → XP_054176527.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A494C0S9

    2. XM_054320556.1 → XP_054176531.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A494C0S9

    3. XM_054320559.1 → XP_054176534.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A494C0S9

    4. XM_054320561.1 → XP_054176536.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A494C0S9

    5. XM_054320558.1 → XP_054176533.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A494C0S9

    6. XM_054320553.1 → XP_054176528.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A494C0S9

    7. XM_054320554.1 → XP_054176529.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A494C0S9

    8. XM_054320555.1 → XP_054176530.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A494C0S9

    9. XM_054320562.1 → XP_054176537.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A494C0S9

    10. XM_054320563.1 → XP_054176538.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X9

    11. XM_054320560.1 → XP_054176535.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A494C0S9

    12. XM_054320557.1 → XP_054176532.1  C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A494C0S9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZJ3.2 GenPept UniProtKB/Swiss-Prot:Q8IZJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools