Kcnk2 potassium channel, subfamily K, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk2provided by MGI
Official Full Name: potassium channel, subfamily K, member 2provided by MGI
Primary source: MGI:MGI:109366
See related: Ensembl:ENSMUSG00000037624 AllianceGenome:MGI:109366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K2P2.1; TREK-1; A430027H14Rik
Summary: Enables channel activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including chloride transmembrane transport; glutamate secretion; and neuronal action potential. Acts upstream of or within G protein-coupled receptor signaling pathway; potassium ion transport; and regulation of membrane potential. Located in astrocyte projection; dendrite; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; early conceptus; limb; olfactory epithelium; and secondary oocyte. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 6.7), cortex adult (RPKM 5.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 94.22 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (188940127..189134951, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (189207930..189402782, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age.
Title: Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age.
Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice.
Title: Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice.
Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages.
Title: Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages.
Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury.
Title: Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A-induced lung injury.
beta-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes.
Title: β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes.
Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Modulating Glutamate Metabolism.
Title: Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Modulating Glutamate Metabolism.
The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood-Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice.
Title: The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood-Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice.
Genetic and pharmacological inhibition of two-pore domain potassium channel TREK-1 alters depression-related behaviors and neuronal plasticity in the hippocampus in mice.
Title: Genetic and pharmacological inhibition of two-pore domain potassium channel TREK-1 alters depression-related behaviors and neuronal plasticity in the hippocampus in mice.
K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury.
Title: K(2P)2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury.
Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification.
Title: Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (4) 1 citation

General gene information

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Markers

Kcnk2 (e-PCR), detects polymorphism
- UniSTS:547593

Kcnk2 (e-PCR), detects polymorphism
- UniSTS:547594

D1Mit362 (e-PCR), detects polymorphism
- UniSTS:116265

RH130296 (e-PCR)
- UniSTS:213582

AI848635 (e-PCR)
- UniSTS:178551

RH125803 (e-PCR)
- UniSTS:162549

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac ventricle development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arachidonate	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission, postsynaptic	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission, postsynaptic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stabilization of membrane potential	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
located_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: potassium channel subfamily K member 2

Names: TREK-1 K(+) channel subunit; outward rectifying potassium channel protein TREK-1; two pore potassium channel TPKC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159850.2 → NP_001153322.1 potassium channel subfamily K member 2 isoform 1

See identical proteins and their annotated locations for NP_001153322.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC121882, AC124527

Consensus CDS

CCDS48480.1

UniProtKB/Swiss-Prot

P97438, Q4VQI2

Related

ENSMUSP00000141891.2, ENSMUST00000193319.6

Conserved Domains (1) summary

pfam07885
Location:139 → 196

Ion_trans_2; Ion channel
NM_001281847.2 → NP_001268776.1 potassium channel subfamily K member 2 isoform 3

See identical proteins and their annotated locations for NP_001268776.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC121882, AC124527

Consensus CDS

CCDS78773.1

UniProtKB/TrEMBL

Q6P6P9

Related

ENSMUSP00000078416.8, ENSMUST00000079451.13

Conserved Domains (1) summary

pfam07885
Location:127 → 184

Ion_trans_2; Ion channel
NM_001281848.1 → NP_001268777.1 potassium channel subfamily K member 2 isoform 4

See identical proteins and their annotated locations for NP_001268777.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK164197, BQ174170

Conserved Domains (1) summary

pfam07885
Location:137 → 215

Ion_trans_2; Ion channel
NM_001357119.2 → NP_001344048.1 potassium channel subfamily K member 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC121882, AC124527

Conserved Domains (1) summary

pfam07885
Location:137 → 215

Ion_trans_2; Ion channel
NM_001402774.1 → NP_001389703.1 potassium channel subfamily K member 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC121882, AC124527, AC132286

UniProtKB/TrEMBL

A0A0A6YXK1

Related

ENSMUSP00000142026.2, ENSMUST00000194402.6
NM_001402775.1 → NP_001389704.1 potassium channel subfamily K member 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC121882, AC124527
NM_001402776.1 → NP_001389705.1 potassium channel subfamily K member 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC121882, AC124527
NM_001402826.1 → NP_001389755.1 potassium channel subfamily K member 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC121882, AC124527
NM_001402827.1 → NP_001389756.1 potassium channel subfamily K member 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC121882, AC124527
NM_010607.4 → NP_034737.2 potassium channel subfamily K member 2 isoform 2

See identical proteins and their annotated locations for NP_034737.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC121882, AC124527

Consensus CDS

CCDS48481.1

UniProtKB/Swiss-Prot

P97438

Related

ENSMUSP00000141849.2, ENSMUST00000192723.2

Conserved Domains (1) summary

pfam07885
Location:124 → 181

Ion_trans_2; Ion channel