Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp2b1provided by RGD
Full Name: cytochrome P450, family 2, subfamily b, polypeptide 1provided by RGD
Primary source: RGD:2466
See related: EnsemblRapid:ENSRNOG00000073837 AllianceGenome:RGD:2466
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cypbe; Cyp2b-1
Summary: Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and steroid hydroxylase activity. Involved in several processes, including response to calcium ion; response to insulin; and response to sulfur dioxide. Located in mitochondrial inner membrane. Biomarker of depressive disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 886.2) and Liver (RPKM 326.0) See more
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (90646098..90669762)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (81518387..81544999)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (99142431..99183540)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrates that CYP2B1 is downregulated in a rat model of chronic kidney disease (CKD). CYP2B1 mRNA level was significantly decreased in CKD relative to control.
Title: The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats.
Data suggest that liver oxidative damage induced by industrial fungicide bromuconazole is due, in part, to up-regulation of PXR/CYP3A1 expression and down-regulation of CAR/CYP2B1 expression. (PXR = pregnane X receptor; CYP3A1 = cytochrome P-450 3A1; CAR = constitutive androstane receptor; CYP2B1 = cytochrome P-450 2B1)
Title: Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression.
Blast-induced traumatic brain injury was found to have a significant impact on CYP2B1 expression in liver.
Title: Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats.
The induction of CYP2B by PB or CFA was comparable to nuclear CAR levels. CAR nuclear translocation was induced by CFA in both rat strains
Title: Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat.
stimulation of hepatic heme oxygenase-1 expression by ascorbic acid deficiency caused the decrease in CYP content in liver
Title: Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats.
Following chemical induction, both microRNA and CYP2B1 expression is increased in liver and ovaries.
Title: Expression of microRNAs, CYP1A1 and CYP2B1 in the livers and ovaries of female rats treated with DDT and PAHs.
After brain injury, hepatic CYP2B1 may be down-regulated via induction of constitutive androstane receptor (CAR)1 disassociation from thyroid hormone receptors.
Title: Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke.
LMP2 contributes to the NO-dependent degradation of CYP2B proteins, and induction of LMP2 may be involved in the potentiation of this degradation by IL-1.
Title: Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2.
analysis of the spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2 and comparison with fluorometric assay
Title: A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2: comparison with fluorometric assay.
Hepatic CYP3A and CYP2B subfamily enzymes are decreased during the development of MT adjuvant-induced arthritis.
Title: Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Hmgc4 (e-PCR)
- UniSTS:260688

Cyp2b10 (e-PCR), detects polymorphism
- UniSTS:462990

D1Wox48 (e-PCR)
- UniSTS:239557

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sulfur dioxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome P450 2B1

Names: CYPIIB1; Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e); P450-B; P450-LM2; P450-PB1 and P450-PB2; P450b; cytochrome P450-B; cytochrome P450-LM2; cytochrome P450-PB1; cytochrome P450-PB2; cytochrome P450b

NP_001128316.1

EC 1.14.14.1

XP_038950984.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134844.1 → NP_001128316.1 cytochrome P450 2B1 precursor

See identical proteins and their annotated locations for NP_001128316.1

Status: PROVISIONAL

Source sequence(s)

BC166502

UniProtKB/Swiss-Prot

P00176, Q64584

UniProtKB/TrEMBL

B2GV28, F1MAD8

Related

ENSRNOP00000073545.3, ENSRNOT00000083650.3

Conserved Domains (1) summary

pfam00067
Location:48 → 488

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

90646098..90669762

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095056.2 → XP_038950984.1 cytochrome P450 2B1 isoform X1

UniProtKB/Swiss-Prot

P00176, Q64584

Related

ENSRNOP00000106041.1, ENSRNOT00000139991.1

Conserved Domains (1) summary

cd20672
Location:88 → 512

CYP2B; cytochrome P450 family 2, subfamily B